Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 400-830-7 | CAS number: 104810-48-2 EVERSORB 80; TINUVIN 1130; TINUVIN 213
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, GLP compliance
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Anex V (with gross necropsy of pubs at day 21 post partum, and histopathological examination of all test and control parental animals including examination of liver and kdneys).
- GLP compliance:
- yes
Test material
- Reference substance name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
- EC Number:
- 400-830-7
- EC Name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
- Cas Number:
- 104810-48-2
- Molecular formula:
- (C2H4O)nC38H40N6O5
- IUPAC Name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene); α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
- Reference substance name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene) α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
- IUPAC Name:
- A mixture of: α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-hydroxypoly(oxyethylene) α-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyl-ω-3-(3-(2H-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl)propionyloxypoly(oxyethylene)
Constituent 1
Constituent 2
Test animals
- Species:
- other: Rat (Tif: RAlf)
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: PEG 300
- Details on exposure:
- Method of administration or exposure: Gavage
Mass median aerodynamic diameter:
EXPOSURE FREQUENCY/DURATION:
Males: daily, for 70 days prior to mating and through the mating period to parturition (ie daily for 96 days, 5 days without treatment, then daily for 19 days).
Femles: Daily for 14 days prior to mating and through mating, pregnancy and lactation. - Analytical verification of doses or concentrations:
- not specified
- No. of animals per sex per dose:
- Male: 25 animals at 0 mg/kg or mg/l
Male: 25 animals at 2 mg/kg or mg/l
Male: 25 animals at 50 mg/kg or mg/l
Male: 25 animals at 100 mg/kg or mg/l
Female: 25 animals at 0 mg/kg or mg/l
Female: 25 animals at 2 mg/kg or mg/l
Female: 25 animals at 50 mg/kg or mg/l
Female: 25 animals at 100 mg/kg or mg/l
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
Minimal-moderate hepatocyte hypertrophy at 50 nd 100 mg/kg and minimal-moderate hepatocyte nerosis in the liver at 100 mg/kg, particularly in males (see comments). Minimal-slight accumulation of iron positive pigment in the liver and kidneys of males at 50 and 100 mg/kg.
There was no evidence of an adverse effect of treatment on reproductive performance of the males or females. No treatment-related pathological effects on the male or female reproductive system were seen.
b) Special investigations of the male liver: Eletron microscopy revealed a striking proliferation of peroxisomes at 50 and 100 mg/kg. Some change in the appearance of peroxisomes was noted at 2 mg/kg. Minor treatment-related effects of smooth endoplasmic reticulum (proliferation) and mitochondria (dilated cristae) were noted at all dose levels. treatment-related changes in enzyme activity, indicative of peroxisome proliferation, were noted at all dose levels.
Results: F1 generation
Details on results (F1)
Clear increase in perinatal mortality at 100 and 50 mg/kg, with slight increase at 2 mg/kg (number of females with stillborn pups: 9,5,2;0 in control group).
At 100 mg/kg there was also: increased prenatal loss, decreased pup survival to day 4 post partum (p.p.) reduced birth weight, slightly reduced mean pup weight (11%) during lactation and slight delay in physical development (eye opening, tooth eruption).
At birth, dark skin (occasionally described as necrotic) was noted on the body, limbs and/or tail of one pup at 50 mg/kg and 25 pups at 100 mg/kg.
Of the pubs surviving to day 21 p.p., a necrotic tip to tail was noted in one at 50 mg/kg and 4 at 100 mg/kg.
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Comments:
Mating schedule: 1 male with 1 female
NO OBSERVED EFFECT LEVELS: Parental animals: < 2 mg/kg/day
F1 generation: < 2 mg/kg/day
No apparent treatment-related adverse effect was observed on the reproductive performance of the P generation, but no information is available on any long-term effect on reproductive performance in the F1 generation.
The substance is clearly fetotoxic, but only minor effects were apparent at weaning. Fetotoxicity appeared to be due primarily to prenatal exposure and not to exposure via the milk. Similar fetotoxic effects were seen in the sighting study.
The description of the parental liver effects detected by light microscopy and reported above is based on a peer review commissioned by the notifier. organising necrosis (nerotic tissue in which granulation tissue is forming) was also noted in the liver, paticularly in males at 50 mg/kg, but the review conluded it to be of doubtful significance (possibly due to infection). The slight increase in single cell hepatocyte necrosis in high dose males was considered to be seondary to accelerated hepatocyte turnover in the enlarged liver. There were no clear treatment-related necrotic liver effects in females.
The special liver studies show that the substance is a potent peroxisome proliferator in the male rat liver.
See also coment of the UK c.a.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.