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EC number: 256-220-4 | CAS number: 45294-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
An experimental study on the structural analogue 2-ethyl hexyl methacrylate (log Kow > 4) (Schäfers, 2006) of bioconcentration of the substance, according to OECD guideline 305 demonstrates that a rapid metabolisation occurs, this depuration prevents any significant accumulation. The measured BCF is 37.
Key value for chemical safety assessment
- BCF (aquatic species):
- 37 dimensionless
Additional information
No study exists for the bioaccumulation of Eicosyl methacrylate.
The octanol/water partition coefficient of the substances, log Kow > 4, predicts a potential for bioaccumulation.
Simple models linking BCF to logKow would give BCF in the range of about > 1000 depending on the model and the logKow used .
On the contrary, an experimental study (Schäfers, 2006) has been carried out on the structural analogue 2-ethylhexyl methacrylate (log Kow > 4) to assess the fish bioconcentration of the substance, according to OECD guideline 305.
This study was conducted with nominal concentrations of 0.06 and 0.3 mg EHMA/l under flow through conditions. An untreated control was run in parallel. Based on a range-finding experiment which indicated rapid metabolism, the uptake phase was scheduled for 56 hours, the depuration phase for 30 hours. Samples of fish (LOQ 0.05 mg/kg) and water (LOQ 0.001 mg/L) were taken at the same time and analysed for 2-Ethylhexyl methacrylate by GC-MS/MS in order to derive the uptake and depuration constants as well as the bioconcentration factor at equilibrium between uptake and elimination. No mortality was observed in the study. During the uptake phase, all concentrations in water and fish were above the LOQ. In the low treatmentgroup, water concentrations rapidly decreased to 50% of nominal during the first 2 h of exposure.
They remained sufficiently constant thereafter. In the high treatment group, water concentrations rapidly decreased to 30% of nominal during the first 4 h of exposure. They remained sufficiently constant thereafter. For steady state calculations the mean of the concentrations in the water of the last five respectively four samplings were used (low 4 – 56 h, high 8 -56 h).
Concentrations in fish increased fast within the first hours and declined later when concentrations in water remained constant. For a worst case estimation, the last two measurements of the concentrations in fish in the low treatment group were not considered further. The steady state BCF was calculated to be 35 and 34 for the low and the high test concentration, respectively. In the depuration phase concentrations in the fish were below LOQ after 16 h. The depuration rates were calculated to be 0.51/h and 0.47/h for the low and the high treatment, respectively.
The depuration half-life is approximately 1.5 h, 95 % is depurated within approximately 6 h. The equilibrium between uptake and depuration (steady state) is already reached after 2 h of exposure. After 12 h, the concentration factor decreased, particularly in the low treatment group and thus was not used for fitting the uptake rate. Uptake rates were calculated to be 19.2/h and 17.4/h for the low and the high test concentration.
From the kinetic rates the BCF of ethylhexyl methacrylate was calculated to be 37 for both test concentrations.
Bioavailability of ethylhexyl methacrylate is expected to be higher than eicosyl methacrylate due to the lower log Pow, lower molecular weight and higher water solublity of ethylhexyl methacrylater (EHMA, C12H22O2: log Pow. 5.59; MW 198.31 g/mol; water solubility: 3.07 mg/l; Eicosyl methacrylate , C24H46O2: log Pow 10.6, MW 366.62 g/mol, water solubility. < 1 µg/l). EHMA and Eicosyl methacrylate are both alkyl methacrylates and the same way of rapid metabolism is expected. Metabolism of EHMA is indeed faster than eicosyl methacrylate, but the concentration of eicosyl methacrylate in organisms is much lower than EHMA due to the lower bioavailability so that bioaccumulation in organisms is also negligible. An exact BCF cannot be estimated but it will also be in the same order of magnitude like EHMA and definitively lower than the criteria for classification and labelling of BCF ≥ 500.
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