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EC number: 700-903-6 | CAS number: 255830-15-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 November - 12 December 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Information lacking on whether the exposure was occlusive or semi-occlusive.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC guidelines - VI Amendment, Annex V, Directive 84/449/EEC
- Deviations:
- yes
- Remarks:
- Lacking information on whether the exposure was occlusive or semi-occlusive.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- pentapotassium {[(hydrogen phosphonomethyl)(phosphonomethyl)-oxo-$l^{5}-azanyl]methyl}phosphonate
- EC Number:
- 700-903-6
- Cas Number:
- 255830-15-0
- Molecular formula:
- C3H7K5NO10P3
- IUPAC Name:
- pentapotassium {[(hydrogen phosphonomethyl)(phosphonomethyl)-oxo-$l^{5}-azanyl]methyl}phosphonate
- Reference substance name:
- ATMP-N-oxide-5K
- IUPAC Name:
- ATMP-N-oxide-5K
- Details on test material:
- - Name of test material (as cited in study report): Sequion CLR
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Italia S.p.A., Via Indipendenza, 11, 22050 - CALCO (Como)
- Age at study initiation: ca. 7-9 weeks
- Weight at study initiation: Males: 225 - 250 grams. Females: 200 - 225 grams
- Housing: 1 animal/cage in air conditioned rooms. Grill cages with stainless steel feeder.
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: Minimum of 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2 °C
- Humidity (%): 55 +/- 10 %
- Air changes (per hr): 20 / hour
- Photoperiod (hrs dark / hrs light): 12 hours dark / 12 hours light
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal and ventral area of the trunk of the test animals.
- % coverage: 10%
- Type of wrap if used: Not specified. Test report states that the treated area was covered with a porous gauze dressing fixed to the skin with tape and further covered in a 'suitable manner' to ensure that the animals could not ingest test material.
REMOVAL OF TEST SUBSTANCE
- Washing: At the end of the exposure period the test substance was wiped off.
- Time after start of exposure: 24 hours.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg bw - Duration of exposure:
- Single administration - 24 hour exposure
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were observed on exposure day at 30 minutes, 2, 4 and 6 hours and on the following 14 days twice per day (early in the morning and late in the afternoon. Body weights were taken once pre-trial, on the administration day and on days 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Since no changes were found at necropsy, histological examination was not performed. - Statistics:
- Since no mortality occurred at the limit dose of 2000 mg/kg, the LD50 was not calculated.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No adverse effects observed
- Mortality:
- No mortality occurred in the treated animals.
- Clinical signs:
- The rats did not show any clinical signs or change in behaviour and no reaction was observed on the application site.
- Body weight:
- Body weight gain of all rats was considered to be within normal limits for animals of this strain and age.
- Gross pathology:
- No changes were observed in the animals killed at the end of the study.
- Other findings:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- An acute dermal toxicity study, conducted according to a standard acute toxicity method and in compliance with GLP, concluded an LD50 value of ≥2000 mg/kg bw/day based on no adverse effects observed.
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