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EC number: 267-008-6 | CAS number: 67762-27-0 This substance is identified by SDA Substance Name: C16-C18 alkyl alcohol and SDA Reporting Number: 19-060-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- ALFOL 1618 alcohol,Hayes Consultancy Service Bromley, Kent
- Author:
- Continental Oil Company.
- Year:
- 1 979
- Bibliographic source:
- Toxicity test summary dated February 8th 1979.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Method: other: in house protocol
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Alcohols, C16-18
- EC Number:
- 267-008-6
- EC Name:
- Alcohols, C16-18
- Cas Number:
- 67762-27-0
- Molecular formula:
- C16 H34 O
- IUPAC Name:
- Alcohols, C16-18
- Test material form:
- solid: compact
- Details on test material:
- - Name of test material (as cited in study report):Tradename Alfol 1618 C16-18 alcohols 100% linear
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS: Rat (Sprague-Dawley)
- Source: Not reported
- Weight at study initiation: 200-245 g
- Group size: 5 (a group of 5 is used at each dose level but it is not clear how the sexes were distributed among the dose levels as the report states both were used). The rats were fasted.
- Controls: none
Sex: male/female
No. of Animals: 20
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 20% aqueous suspension prepared in 0.5% gum tragacanth
- Details on oral exposure:
- Vehicle: other: 20% aqueous suspension prepared in 0.5% gum tragacanth
Doses: 2, 4, 5 and 10 g/kg, - Doses:
- Doses: 2, 4, 5 and 10 g/kg,
- No. of animals per sex per dose:
- Group size: 5 (a group of 5 is used at each dose level but it is not clear how the sexes were distributed among the dose levels as the report states both were used).
- Control animals:
- no
- Details on study design:
- ADMINISTRATION: Gavage
- Doses: 2, 4, 5 and 10 g/kg (based on range finding test)
- Doses per time period: single
- Volume administered or concentration: 20% aqueous suspensioin in 0.5% gum tragacanth.
- Post dose observation period: 14 days
EXAMINATIONS: Mortality was recorded.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No animals died.
- Clinical signs:
- other: Not reported.
- Gross pathology:
- No significant gross abnormalities were seen at autopsy.
- Other findings:
- NECROPSY FINDINGS: Not carried out.
POTENTIAL TARGET ORGANS: None identified.
SEX-SPECIFIC DIFFERENCES: Combined test group.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 in male/female rats is >10000 mg/kg bw . No significant gross abnormalities were seen at autopsy.
The rat oral LD50 for Alcohols, C16-18 was >10000 mg/kg bw. - Executive summary:
The rat oral LD50 for Alcohols, C16-18 was >10000 mg/kg bw.
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