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EC number: 205-011-6 | CAS number: 131-11-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
DMP did neither initiate nor promote cancer in a 1-year study in male CD-1 mice (NTP, 1993).
Key value for chemical safety assessment
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 2 700 mg/kg bw/day
- Study duration:
- chronic
- Species:
- mouse
Justification for classification or non-classification
GHS classification (GHS UN rev.2, 2007): no classification required
Additional information
DMP-Carcinogenicityin vivo, Initiation/promotion study
DMP was tested in male CD-1 mice [NTP, 1993] for one year with one dose of 0.1 ml (calculated 2700 mg/kg bw; density=1.194g/ml). Neat substance was applied dermally on clipped skin over one year. In parallel DMBA (7,12-dimethylbenz(a)anthracene) and TPA (12-O-tetradecanoylphorbol-13-acetat) were used as positive controls for initiation and promotion, respectively. Combined treatment of DMBA and TPA lead to an increase of both squamous cell papillomas and squamous cell carcinomas. All TPA-dosed groups had significantly greater incidences of dermal acanthosis, ulceration, exudation, and hyperkeratosis than controls. Therefore the TPA exposure concentration was adjusted to 0.025 mg/ml (2x per week) from week 10 on (starting concentration: 0.05 mg/ml 3x per week).DMP treatment had no effect on body weight compared to vehicle controls.Incidences of neoplasms in the DMP treated mice (initiation) were similar to vehicle controls. Thus, DMP was not able to initiate skin carcinogenesis when chronically promoted by TPA. Furthermore, DMP did not promote skin carcinogenesis in skin initiated with DMBA. The test substance is not carcinogenic, nor does it initiate and/or promote cancer.
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