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EC number: 211-670-0 | CAS number: 683-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 August - 17 August 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Source and purity of the test substance not reported. Only one animal exposed to test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The local dermal tolerance of ZK 22.663 was tested on the intact skin of 1 male rabbit after a single application under semi-occlusive conditions. One intact skin area (2.5 x 2.5 cm each) was treated with a paste containing 0.5 g ZK 22.633/0.2 mL 0.9% (w/v) NaCl solution for 4 hours whereas the corresponding control area remained untreated. The local reactions were recorded within 30-60 minuts after exposure and thereafter once daily until day 3 of the test.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dibutyltin dichloride
- EC Number:
- 211-670-0
- EC Name:
- Dibutyltin dichloride
- Cas Number:
- 683-18-1
- Molecular formula:
- C8H18Cl2Sn
- IUPAC Name:
- dibutyltin dichloride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Schriever
- Age at study initiation: nda
- Weight at study initiation: 2.8 kg
- Housing: Metal cage
- Diet: pell. Altromin K, ad libitum
- Water: Demineralised water, ad libitum
- Acclimation period: > 2 weeks, feeding during acclimation consisted of a diet containing 0.03% sulfaquin-oxaiine for 7 consecutive days for coccidioses prophylaxis
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-24°C
- Humidity (%): 55-57%
- Air changes (per hr): nda
- Photoperiod (hrs dark / hrs light): 12 hours day/night cycle
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: 0.9% (w/v) NaCl solution
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5g
- Concentration (if solution): 0.5g of the test material was moistened with 0.2 ml 0.9% w/v NaCl solution to form a paste.
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.2 ml 0.9 % w/v NaCl solution - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 days in total; 30 - 60 minutes after exposure, and thereafter every 24 hours till day 3 of the test, clinical observations were made and findings recorded.
- Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- % coverage: nda
- Type of wrap if used: Sites were covered with a piece of gauze (semiocclusive) fixed on the skin with Leukoflex®.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After exposure the gauze was removed and the treated and untreated skin areas were wiped off carefully with lukewarm tap water and cotton wool
- Time after start of exposure: 30 - 60 minutes after exposure, and thereafter every 24 hours till day 3 of the test, clinical observations were made and findings recorded.
SCORING SYSTEM:
Draize scoring
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Draize
- Basis:
- animal #1
- Time point:
- other: 3 days
- Score:
- 6.3
- Reversibility:
- no data
- Irritant / corrosive response data:
- The irritation index according to Draize was 6.3 for the animal, indicative of severe local irritation.
- Other effects:
- Swellings, reddening, induration, scab formation, vesiculation and beginning of necrosis at the application site.
Macroscopic findings (necropsy) revealed a severe thickening of skin and subcutis and formation of eschar. Further a wet cut surface of the skin was observed.
Any other information on results incl. tables
It should be taken into consideration that the rabbit skin has proved to be more sensitive towards tributyltin compounds in former studies compared with human's skin. Thus, although skin necrosis might not be expected, less severe alterations like reddening and swelling might occur after inadvertent contact of the test material with the human skin.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- The irritation index according to Draize was 6.3 for this animal, indicating severe irritation.
- Executive summary:
In a local dermal tolerance test in rabbits after a single application (Schering report number: IC 29/89) the test material was found to be severely irritation according to the draize score of 6.3.
Application of the test material led to swellings, reddening, induration, scab formation, vesiculation and beginning of necrosis at the application site.
Macroscopic findings (necropsy) revealed a severe thickening of skin and subcutis and formation of eschar. Further a wet cut surface of the skin was observed.
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