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Diss Factsheets
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EC number: 932-121-8 | CAS number: 1147459-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A BCF value has been calculated using the BCFBAF module in EPIWEB 4.1. The half-lives as used in this model are in good agreement with the half-lives observed in the in-vitro biotransformation tests. This is not only observed in this test but has also been demonstrated for other cationic surfactants. Using this model a BCF of 33.7 L/kg is calculated.
Key value for chemical safety assessment
- BCF (aquatic species):
- 33.7 L/kg ww
Additional information
N-[3 -(dimethylamino)propyl]-C12-18(even numbered)-alkylamide (=cocoamidopropyl dimethylamine) is a cationic surfactant which is readily biodegradable and sorbs strongly to negative charged surfaces. Performance of a standard aquatic exposure based OECD 305 test is technically very complicated with substances with this type of properties. The bioaccumulation potential of cocoamidopropyl dimethylamine was therefore estimated using the measured log Kow of 4.3. This log Kow value is based on the ratio of the solubility in octanol and the observed CMC and indicates that cocoamidopropyl dimethylamine may have a moderate bioaccumulation potential in case the substance would have been a neutral chemical. Cationic surfactants are however not easily absorbed and when absorbed cocoamidopropyl dimethylamine will be rapidly degraded in fish as has been demonstrated in an in-vitro biotransformation test.
In this in-vitro biotransformation test N cocoamidopropyl dimethylamine was tested using rainbow trout hepatic S9 subcellular fraction in a procedure according to a slightly adapted Cellzdirect/Invitrogen Hepatic Rainbow Trout S9 Incubation Protocol. Metabolisation by rainbow trout liver S9 fractions was evaluated using a substrate depletion approach. The fish capabilities to metabolize was checked with bis(2 -hydroxyethyl) laurylamine as reference substance at an initial test concentration of 1 μmol/L.
The observed half-lives for range from 2.2 hour for the C12 upto 13.3 hour for the C18. These half-lives strongly support the conclusion that the substances will be rapidly degraded in fish if taken up.
The result with the reference substance for which a half-life of 1.53 hour was observed, shows that the S9 fraction is performing as expected based on the mean historical half-life of this substance of 1.54 ± 0.35 hour (n=11).
The observed rapid biotransformation of the C12 to C18 constituents of cocoamidopropyl dimethylamine strongly indicate that it will be very unlikely that these substances will accumulate to a high extend in fish. It is therefore concluded that cocoamidopropyl dimethylamine has a low bioaccumulation potential.
Based on the rapid biotransformation in fish and ready biodegradability of the substance it is very unlikely that cocoamidopropyl dimethylamine will accumulate in the food chain.
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