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Diss Factsheets
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EC number: 236-751-8 | CAS number: 13473-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Published review
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The US ATSDR Toxicological Profile for Aluminium contains a comprehensive and authoritative review of the toxicokinetic properties of aluminium in various forms
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicological Profile for Aluminium
- Author:
- ATSDR
- Year:
- 2 008
- Bibliographic source:
- U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Review of the toxicokietics of various forms of aluminium based on available literature data
- GLP compliance:
- no
Test material
- Reference substance name:
- various forms of aluminium
- IUPAC Name:
- various forms of aluminium
Constituent 1
Test animals
- Species:
- other: not applicable
Administration / exposure
- Route of administration:
- other: not applicable
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The bioavailability of aluminium is strongly influenced by the aluminium compound and also by the presence of dietary constituents which can complex with aluminium and thereby enhance or inhibit its absorption. The main mechanism of absorption is passive diffusion through paracellular pathways.
- Details on distribution in tissues:
- Aluminium binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues.
- Details on excretion:
- Absorbed aluminium is excreted principally in the urine and, to a lesser extent, in the bile.
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Not applicable
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- Not considered
Any other information on results incl. tables
This review concludes that aluminium is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. Approximately 0.1-0.6% of ingested aluminium is usually absorbed,
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
This review concludes that aluminium is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. Approximately 0.1-0.6% of ingested aluminium is usually absorbed. - Executive summary:
This review concludes that aluminium is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. Approximately 0.1-0.6% of ingested aluminium is usually absorbed, although the gastrointestinal absorption of some forms of aluminium may be lower. Unabsorbed aluminium is excreted in the faeces. The bioavailability of aluminium is strongly influenced by the aluminium compound and also by the presence of dietary constituents which can complex with aluminium and thereby enhance or inhibit its absorption. The main mechanism of absorption is passive diffusion through paracellular pathways. Aluminium binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. Absorbed aluminium is excreted principally in the urine and, to a lesser extent, in the bile.
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