Registration Dossier
Registration Dossier
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EC number: 254-875-0 | CAS number: 40292-82-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a valid pre-guideline LLNA groups of mice are exposed daily, for 3 consecutive days, to various concentrations of nonanoyl chlorid or to the relevant vehicle alone, on the dorsum of both ears. On day 5 following the initiation of exposure, mice are injected intravenously with [3H]thymidine and activity measured as a function of isotope incorporation in draining auricular lymph nodes (Kimber and Basketter, 1992). A stimulation index ≥ 3, together was observed in all concentration. Therfore nonanoyl chloride is regarded as sensitizing in the LLNA. The same result is expected for Neodecanoyl chloride due to structural similarity.
Migrated from Short description of key information:
Nonanoyl chloride is regarded as sensitizing in the LLNA. The same result is expected for Neodecanoyl chloride due to structural similarity.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
no testsystem and no data available.
Justification for classification or non-classification
Nonanoyl chloride is regarded as sensitizing in the LLNA. The same result is expected for Neodecanoyl chloride due to structural similarity.
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