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EC number: 231-831-9 | CAS number: 7758-05-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Potassium iodide (KI) was fed to male and female rats before and during breeding, to females only during gestation and lactation, and to their offspring after weaning (day 21 after birth) through to day 90, at levels of 0, 0.025, 0.05 or 0.1% (w/w) of the diet. Dams in a fifth group (positive controls) were given 4 mg/kg ip of the anti-mitotic/cytotoxic drug 5-azacytidine on day 17 of gestation
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium iodide
- EC Number:
- 231-659-4
- EC Name:
- Potassium iodide
- Cas Number:
- 7681-11-0
- Molecular formula:
- IK
- IUPAC Name:
- potassium iodide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female Sprague-Dawley rats (200-240 g; Laboratory Supply Co., Indianapolis, IN) were obtained.
Administration / exposure
- Route of administration:
- oral: feed
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Male and female Sprague-Dawley rats (200-240 g; Laboratory Supply Co., Indianapolis, IN) were acclimatized to the laboratory for 5 days before assignment to groups given diets (Purina rat chow meal) supplemented with 0 (two control groups), 0.025, 0.05 or 0.1% (w/w) potassium iodide.
Negativecontrol dams received no treatment.
Positive-control dams were given two ip injections of 2 mg/kg of S-azacytidine on day 17 of gestation.
Dietary treatments were given continuously to both males and females for 14 days before mating and for 1-14 days during breeding, and to females only during gestation (22 days) and lactation (21 days). After weaning, the offspring were given dietary potassium iodide, at the level their parents had received, throughout the remainder of the experiment. - Duration of treatment / exposure:
- 17-90 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 0.025, 0.05 or 0.1% (w/w)
Basis:
nominal in diet
- Control animals:
- yes
- Positive control:
- yes
Examinations
- Parental animals: Observations and examinations:
- KI delayed auditory startle at the two highest doses, delayed olfactory orientation to the home-cage scent at the middle dose and decreased female running-wheel activity at all dose levels. In rats killed on day 90 after birth KI reduced brain and body weight at a dose of 0.1% of the diet, and reduced body but not brain weight at a dose of 0.05% of the diet.
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
resulted in only a marginal decrease in body weight (P < 0.09). No effects were found on maternal food consumption or body weight during gestation
Effect levels (P0)
- Dose descriptor:
- other: Not available
- Sex:
- male/female
- Basis for effect level:
- other: Effect level not known
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
Mortality of offspring from rats fed 0-0.1~ potassium iodide in the diett |
|||||
Mortality (%) |
|||||
|
|
|
Potassium iodide groups |
||
Age (days): |
Negative control |
Positive control |
0.025% |
0.05% |
0.1% |
0-1 |
0.0 |
12.3"* |
0.9 |
0.5 |
6.0** |
2-24 |
13.1 |
28.6** |
5.1 * |
14.8 |
21.9* |
25-90 |
1.0 |
0.0 |
1.4 |
4.0 |
5.2 |
tArter weaning (day 21) offspring were fed potassium iodide in their diet at the same level fed to their parents.Birth date considered to be day 0.
§Positive-control dams received two ip injections of 5-azacytidine on day 17 of gestation.
Values marked with asterisks differ significantly from the corresponding negative-control value:*P < 0.05; **P < 0.01
Applicant's summary and conclusion
- Conclusions:
- All offspring were reared by their natural dams and were evaluated blind with respect to treatment in a battery of standardized behavioural tests between 3 and 90 days of age. KI produced no significant reductions in parental body weight or food consumption, though it significantly reduced litter size and increased offspring mortality at the highest dose, and decreased weight gain at the two highest doses throughout the first 90 days after birth.
- Executive summary:
Potassium iodide produced no significant reductions in parental body weight or food consumption, though it significantly reduced litter size and increased offspring mortality at the highest dose, and decreased weight gain at the two highest doses throughout the first 90 days after birth.
In rats killed on day 90 after birth KI reduced brain and body weight at a dose of 0.1% of the diet, and reduced body but not brain weight at a dose of 0.05% of the diet. No significant effect was found on absolute or relative thyroid weight at 90 days of age.
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