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Diss Factsheets
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EC number: 415-510-2 | CAS number: 145703-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The substance is non-irritant to skin and eye of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Local changes induced by the substance at the site of contact, namely skin and eye, were evaluated irrespective of whether the substance may become systemically available. Skin and eye irritation of the substance was tested on rabbits by topical application and instillation, respectively. As for the dermal application, pink staining of the treated skin was seen during the whole observation period. As for the eye instillation, no effects on cornea and iris and signs of conjuctivae chemosis were seen. The conjuctivae redness was observed in female rabbits, but the relative scores were below the threshold for classification of the substance as irritant.
The dermal exposure to the substance induced no systemic symptoms in animals during the test and observation period, and no mortality. One female lost weight during the acclimatisation period, while the body weight gain of other animals was not affected during the study period.
Similarly, in the case of eye, no clinical signs of systemic toxicity were seen and no mortality occurred. The body weight of the animal was within the normal range of variability.
Under the test conditions, during the observation period, the substance did not induce systemic toxicity.
Justification for selection of skin irritation / corrosion endpoint:
The study is reliable and representative.
Justification for selection of eye irritation endpoint:
The study is reliable and representative.
Justification for classification or non-classification
The substance is not classified according to the CLP Regulation (EC 1272/2008). As for skin irritation, the mean scores for erythema and edema at 24, 48 and 72 hours are lower than threshold level of 2.3 for at least 2 of 3 animals.
As for eye irritation, the averaged scores at 24, 48 and 72 hours for at least 2 of 3 animals are lower than the threshold level of 1 for cornea and iris, and lower than threshold level of 2 for conjuctivae redness and chemosis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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