Registration Dossier
Registration Dossier
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EC number: 206-119-6 | CAS number: 302-23-8
Endpoint summary
Administrative data
Description of key information
Skin irritation (Rat-Wistar, GLP, non-audited report, OECD TG 402 & 404): not irritating or corrsosive to skin
[Schering AG, Report No. X058; 1996-01-09]
Eye irritation (Rabbit-NZW, GLP, non-audited report, OECD TG 405): not irritating
[Schering AG, Report No. X083; 1996-04-15]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
ZK 5189 did not show a skin irritating or corrosive potential in rats when administered semi-occlusively to the shorn back for 24 hours. [Schering AG, Report No. X058; 1996-01-09]
ZK 5189 provoked very slight to slight transient irritations (slight to moderate reddening and vascular injection of the conjunctivae, reddening of iris in one animal 1 hour after application) on the rabbit conjunctiva after single conjunctival application on the day of administration. ZK 5189 is not regarded as an eye irritant. [Schering AG, Report No. X083; 1996-04-15]
Justification for classification or non-classification
Based on the results there is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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