N-(N6-trifluoroacetyl-L-lysyl)-L-proline

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1993-05-13 to 1993-07-26

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.12 (Flammability (Contact with Water))

Version / remarks:

84/449/EC

Deviations:

no

GLP compliance:

yes

Key result

Test procedure:

step 1

step 2

step 3

step 4

Remarks on result:

no reaction with water observed

None of the three tests carried out showed any gas-evolution or ignition of builded gas. Therefore the test substance ε-Trifluoroacetyl-L-lysyl-L-proline is to be classified as non highly inflammable in contact of water or damp.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

None of the three tests carried out according to Directive 84/449/EEC, A.12 showed any gas-evolution or ignition of built gas. Therefore the test substance ε-Trifluoroacetyl-L-lysyl-L-proline is to be classified as non highly inflammable in contact of water or damp.

Reference 2

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1993-05-13 to 1993-07-19

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Version / remarks:

84/449/EEC

Deviations:

no

GLP compliance:

yes

Key result

Test procedure:

burning rate test over 100 mm length

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

Result:

At the time the glowing platinum wire was inserted the substance began to burn and melted. But the burning was only in the surroundings of the ignition centre. After a very short time of burning the flame extincted. No spread out of flames.

There was no measureable burning time in any of the six tests. As defined in the EEC-guideline A.10. the test substance ε-Trifluoroacetyl-L-lysyl-L-proline is to be classified as non highly inflammable .

Interpretation of results:

not classified based on GHS criteria

Conclusions:

There was no measureable burning time in any of the six tests. As defined in Directive 84/449/EEC, A.10 the test substance ε-Trifluoroacetyl-L-lysyl-L-proline is to be classified as non highly inflammable.

Description of key information

Not highly flammable (EEC method A.10., GLP).

Non highly inflammable in contact of water or damp (EEC method A.12., GLP).

Key value for chemical safety assessment

Flammability:

not classified

Additional information

The substance was determined to be not highly flammable in a GLP study conducted according to Directive 84/449/EEC A.10.

The substance was determined to be not highly flammable in contact with water or damp in a GLP study conducted according to Directive 84/449/EEC A.12.

In accordance with Regulation (EC) 1272/2008, Annex I Section 2.10.4.1 "The classification procedure for pyrophoric solids need not be applied when experience in manufacture or handling shows that the substance does not ignite spontaneously on coming into contact with air at normal temperatures (i.e. the substance is known to be stable at room temperature for prolonged periods of time (days))." The substance is known to be stable in contact with air at room temperature for prolonged periods of time (days) and therefore a test for "pyrophoric solids" according to Regulation (EC) 440/2008 A.13. does not need to be conducted.

Justification for classification or non-classification

The substance is classified as not highly flammable in accordance with Regulation (EC) No. 1272/2008 (CLP) and the Globally Harmonized System for Classification and Labelling of Chemicals (GHS).