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EC number: 221-374-3 | CAS number: 3081-01-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute dermal and oral toxicity of the test substance 7PPD is very low, indicated by oral LD50 values greater than 2000 mg/kg. The acute oral LD50 value in rats is = 2100 mg/kg bw (Monsanto Co. 1973, 1967a) and the dermal LD50 value in rabbits is greater than 5010 mg/kg bw (Monsanto Co. 1973, Monsanto Co. 1967a).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- other: acute oral toxicity study
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1260, 1580, 2000, 2510, 3160 mg/kg
- No. of animals per sex per dose:
- combined (male/females): 5 per dose
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 100 mg/kg bw
- 95% CL:
- 2 000 - 2 200
- Remarks on result:
- other: clinical signs: reduced appetide and activivty (survivors), increasing weakness, collapse and death (decedents),; gross autopsy: vicera appeared normal (survivors), hemorrhagic areas of the lung, liver discoloration, acute gastrointestinal inflammation
- Executive summary:
LD50 rat: 2100 mg/kg bw
Reference
Mortality:
time to mortality: one to four days after application
1260 mg/kg bw: 0/3 males, 1/2 females, combined: 1/5
1589 mg/kg bw: 0/2 males, 2/3 females, combined: 2/5
2000 mg/kg bw: 0/3 males, 2/2 females, combined 2/5
2510 mg/kg bw: 0/2 males, 3/3 females, combinded 3/5
3160 mg/kg bw: 2/3 males, 2/2 females, combinded 4/5
Signs of intoxication: reduced appetite and activity (two to four days in survivors), increasing weakness, collapse and death.
Gross autopsy decedents: hemorrhagic areas of the lung, liver discoloration, and acute gastrointestinal inflammation
Survivors (7 days): vicera appeared normal
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 100 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- other: acute dermal toxicity study
- GLP compliance:
- no
- Test type:
- other: acute dermal toxicity study
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 h
- Doses:
- 5010, 7940 mg/kg
- No. of animals per sex per dose:
- 1 to 2 per dose
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010
- Remarks on result:
- other: Clinical signs: reduced appetite and activity (survivors), increasing weakness, collapse and death (decents); gross autopsy:hemorrhagic areas of the lung, liver, spleen, and kidney discoloration, gastrointestinal inflammation (decents)
- Executive summary:
LD50 rabbit: >5010 mg/kg
Reference
Mortality:
time of mortality: 8 days
5010 mg/kg: 0/1 male
7940 mg/kg: 1/1 male, 0/1 female, combinded: 1/2
Signs of intoxication: reduced appetite and activity (four to seven days in survivors), increasing weakness, collapse and death (decent)
Gross autopsy:
Decent: hemorrhagic areas of the lung, liver, spleen, and kidney discoloration, gastrointestinal inflammation
Survivors (14 days): Viscera appeared normal
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 010 mg/kg bw
Additional information
Acute toxicity: oral
The acute oral toxicity of 7PPD was evaluated in two early acute oral toxicity studies in rats. Although the study results are reliable the test design of the studies does not comply with the current guidelines. In an acceptable documented study with Sprague-Dawley Albino rats undiluted test substance was administered by gavage to male and female rats at doses of 1260, 1580, 2000, 2510 and 3160 mg/kg bw. A 7-day observation period followed administration. The oral LD50 calculated was 2100 mg/kg bw. Mortality occurred (1 to 4 days after application) in all dose groups evaluated (1/5, 2/5, 2/5, 3/5, 4/5 at 1260, 1580, 2000, 2510, 3160 mg/kg bw, respectively). Clinical signs were observed and included reduced appetite and activity (two to four days in survivors), increasing weakness, collapse and death. Autopsy of decedent showed hemorrhagic areas of the lung, liver discoloration and acute gastrointestinal inflammation; viscera of surviving animals appeared normal at sacrifice (Monsanto Co. 1973). In another acceptable documented acute oral toxicity study with Sprague-Dawley rats, an oral LD50 of 2170 mg/kg bw was calculated (Monsanto Co. 1967a). The test substance 7PPD was suspended in corn oil and were orally administered as a 25 % solution to four groups of 5 rats (mixed males and females) at doses of 1580, 2000, 2510 and 3160 mg/kg bw. Mortality occurred in all treatment groups (1/5, 1/5, 3/5, 5/5 at 1580, 2000, 2510, 3160, respectively). The clinical signs observed were weakness in one or two hours, diarrhea, tremors, and collapse. Autopsy revealed inflammation of the gastric mucosa, kidney and liver discoloration (greenish hue), and pulmonary hyperemia. In an additional study (Monsanto Co. 1967b), which was conducted to clarify the findings from the autopsy, no greenish hue of the liver was seen.
Acute toxicity: dermal
The acute dermal toxicity of 7PPD was evaluated in an acceptable documented acute dermal toxicity study with New Zealand Albino rabbits. Male and female rabbits (one to two animals per dose) were treated for 24 hours with undiluted test substance at doses of 5010 and 7940 mg/kg bw. Mortality occurred in the highest dose group 8 days after test substance application (1/2). Clinical signs observed included reduced appetite and activity (four to seven days in survivors), increasing weakness, collapse, and death. Gross autopsy of decedent revealed hemorrhagic areas of the lung, liver, spleen, and kidney discoloration and gastrointestinal inflammation; viscera of surviving animals appeared normal at sacrifice (Monsanto Co. 1973). The findings from the above mentioned study were confirmed in an additional experiment with 7PPD in New Zealand Albino rabbits, where a dermal LD50 greater than 10000 mg/kg was obtained (Monsanto Co. 1967a).
Justification for classification or non-classification
No classification is required according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
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