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EC number: 205-535-5 | CAS number: 142-31-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 June 2012 - 30 August 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study conducted in compliance with GLP regulations
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium octyl sulphate
- EC Number:
- 205-535-5
- EC Name:
- Sodium octyl sulphate
- Cas Number:
- 142-31-4
- Molecular formula:
- C8H18O4S.Na
- IUPAC Name:
- sodium octyl sulfate
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): Trade name given
- Substance type: pure substance
- Physical state: solid, white
- Analytical purity: 92.5% octyl sulphate, sodium salt (determined by the manufacturer, non-GLP)
- Lot/batch No.: 12076LW115
- Expiration date of the lot/batch: March 06, 2013
- Stability under test conditions: stable
- Storage condition of test material: ambient (RT); store frost-free; avoid temperatures >30 °C
- Test item No.: 12/0257-1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Details on strain: Wistar / Crl:WI (Han)
- Source: Charles River Wiga GmbH, Sandhofer Weg 7, 97633 Sulzfeld, Germany
- Age at study initiation: approx. 10 weeks
- Weight at study initiation: mean (1st group): 169.7 ± 4.16g; mean (2nd group): 179.3 ± 10.02g
- Fasting period before study: Feed was withdrawn from the animals at least 16 hours before administration, but water was available ad libitum.
- Housing: single housing in Makrolon cage, type III
- Diet (ad libitum): VRF1(P); SDS Special Diets Services, 67122 Altrip, Germany
- Water (ad libitum): Tap water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22°C ± 3°C
- Humidity: 30 – 70%
- Air changes (per hr): approx. 10
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- deionized
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 g/100 mL
- Amount of vehicle (if gavage): 10 mL/kg bw
- Justification for choice of vehicle: Solution in deionized water.
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
CLASS METHOD
- Rationale for the selection of the starting dose:
By request of the sponsor a starting dose of 2000 mg/kg bw was chosen in the first step with 3 female animals. As only one animal died, 2000 mg/kg bw were administered to 3 female rats in the second step. - Doses:
- Starting dose: 2000 mg/kg bw
Second step dose: 2000 mg/kg bw - No. of animals per sex per dose:
- 3 female rats per test group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: A check for any dead or moribund animals was made at least once each workday.
- Necropsy of survivors performed: yes
Necropsy with gross-pathology examination on the last day of the observation period after sacrifice by CO2-inhalation in a chamber with increasing concentrations over time. Necropsy of the animal that died during the study as early as possible after death.
- Other examinations performed:
Clinical signs: Recording of clinical signs several times on the day of administration, and at least once daily thereafter each workday for the individual animals.
Body weight: Individual body weights shortly before administration (day 0), weekly thereafter and on the last day of observation.
Histopathology: No histological examinations were performed.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- In the first 2000 mg/kg bw test group one animal was found dead at hour 5 after administration.
No mortality occurred in the second test group. - Clinical signs:
- other: 1st group: Clinical signs in the two surviving animals of the first 2000 mg/kg bw test group revealed impaired general state, dyspnoea and piloerection from hour 1 until hour 5 after administration. In the animal that died in this test group poor general
- Gross pathology:
- Deceased animal:
In the animal that died in the first test group the following macroscopic pathologic findings were observed: Liquid, light discolored content in the stomach, red discoloration of the glandular stomach and small intestine.
Sacrificed animals:
There were no macroscopic pathological findings in the surviving animals sacrificed at the end of the observation period.
Any other information on results incl. tables
Body weight changes:
Individual body weight changes |
||||||||||
Dose [mg/kg bw] |
2000 |
2000 |
||||||||
Group |
1 |
2 |
||||||||
Animal No. |
1 |
2 |
3 |
mean |
sd. |
1 |
2 |
3 |
mean |
sd. |
Body weight at study day [g] |
|
|
|
|
|
|
|
|
|
|
0 |
165 |
171 |
173 |
169.7 |
4.16 |
183 |
187 |
168 |
179.3 |
10.02 |
7 |
182 |
182 |
- |
182.0 |
0.00 |
195 |
203 |
187 |
195.0 |
8.00 |
14 |
184 |
192 |
- |
188.0 |
5.66 |
206 |
212 |
201 |
206.3 |
5.51 |
sd. = standard deviation
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.