Registration Dossier
Registration Dossier
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EC number: 219-295-4 | CAS number: 2404-44-6
Endpoint summary
Administrative data
Description of key information
Additional information
Toxicity to fish, acute:
The short-term toxicity to fish was tested with Poecilia reticulata (guppy) in a non-standard study equivalent or similar to OECD 203. In a 14 -day semi-static study with at least 5 different concentrations with a geometrically increasing factor of 1.8, 10 fish were exposed to each concentration. The LC50 -values were calculated from log-it analysis. In this test, the test item revealed a LC50 of 1.11 mg/L (Deneer et al., 1988)
Toxicity to Daphnia, acute:
Daphnia magna was exposed towards the test item in an OECD 202 test. After 48h the EC50 was determined to be 0.171 mg/L (mean mesured).
Toxicity to Daphnia, chronic:
In a 21-day chronic semi static toxicity study, Daphnia magna were exposed to Decyloxirane at nominal concentrations of 0 (control), 0.07 mg/L, 0.10 mg/L, 0.15 mg/L, 0.22 mg/L and 0.33 mg/L (corresponding to time-weighted measured concentrations of 0 (control), 0.087 mg/L, 0.116 mg/L, 0.196 mg/L, 0.226 mg/L and 0.287 mg/L) in accordance with the OECD 211 guideline. Measured concentrations deviated mostly more than 20% from the nominal concentration. Therefore, results of this study are based on time-weighted mean measured concentrations.
LOEC = 0.116 mg/L
NOEC = 0.087 mg/L
EC10 = 0.091 mg/L
Toxicity to algae, acute/chronic:
Two guideline studies (OECD 201) according to GLP with Pseudokirchneriella subspicata are available for Decyloxirane. The EC50 of the first study was determined to be 0.0557 mg/l and the NOEC was determined to be 0.00416 mg/l based on mean measure concentrations. The EC50 of the second study was 0.52 mg/l and the EC10 0.25 mg/l related to growth rate based on initial measured concentrations.
Due to analytical inconsistencies of the first study and subsequent performed additional studies (hydrolysis: OECD 111 / second study OECD 201) the first study has to be re-evaluated in the light of the additional findings (see justification). Therefore, the key values for algae were derived from the second study being EC50: 0.52 mg/l and EC10 0.25 mg/l, respectively.
Toxicity to microorganisms:
A new guideline study (OECD 209) according to GLP is available for decyloxirane. After 3h exposure the EC10 and EC50 were determined to be 36 mg/l and > 1000 mg/l, respectively.
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