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Diss Factsheets
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EC number: 241-866-1 | CAS number: 17927-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Weight of evidence
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The physico-chemical parameters as well as the bio-concentration factors can provide reliable indiactions on the toxico-kinetic behavior of a chemical & whether the chemical shall have a tendency to bio-accumulate.
Data source
Reference
- Reference Type:
- other: Weight of evidence
- Title:
- Toxicokinetics
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Based on the weight of evidence of various phys chem and bioaccumulative parameters in the dossier
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- EC Number:
- 241-866-1
- EC Name:
- Bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- Cas Number:
- 17927-72-9
- Molecular formula:
- C16H28O6Ti
- IUPAC Name:
- bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- Not applicable
Constituent 1
Test animals
- Species:
- other: unspecified
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not applicable
Administration / exposure
- Route of administration:
- other: estimation
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Not applicable
- Duration and frequency of treatment / exposure:
- Not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not applicable
- No. of animals per sex per dose / concentration:
- Not applicable
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Not applicable
- Details on dosing and sampling:
- Not applicable
- Statistics:
- Not applicable
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The absorption capacity of bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium through the inhalation route is expected to be low since it is a liquid with very low vapour pressure (0.000000003 Pa). The use of the chemical suggest that the dermal route is expected to be the most dominant route of exposure. However there is no information on the dermal absorption of this chemical.
- Details on distribution in tissues:
- If the chemical substance,bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium, is absorbed through the dermal route, it shall be distributed more in the lipid fraction of the body fluid than in the blood since the solubility of the chemical is low in water compared to the organic solvents.
- Details on excretion:
- The bio-concentration factor (BCF) of bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium is very low i.e. 3.162. This value is extrremely low compared to the threshold value of 2000 to suggest bio-accumulation. Thus, the chemical is unlikely to bio-accumulate within the living system and shall be excreted out of the living system quickly either through the urine, excreta or bile. In addition, the Log Kow value of bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium is low i.e. 0.741 suggesting reduced bio-availability. Thus, the chemical is exepected to be excreted mostly unchanged out of the living system.
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- Not applicable
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Low bioaccumulation potential based on estimation results
The substance, bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium, is expected to have low bioaccumulation potential based on estimation results supported by the weight of evidence of the physicochemical parameters and low BCF value and reduced bio-availability of the chemical. - Executive summary:
The substance, bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium, is expected to have low bioaccumulation potential based on estimation results supported by the weight of evidence of the physicochemical parameters and low BCF value and reduced bio-availability of the chemical.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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