Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-793-5 | CAS number: 17832-28-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
4-(vinyloxy)butan-1-ol is acutely harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
Assessment of the toxicity of 4 -(vinyloxy)butan-1 -ol towards aquatic invertebrates is based on data available for two close structural analogous substances: 2-methyl-1-(vinyloxy)propane and 2 -(vinyloxy)ethanol.
The toxicity of 2-methyl-1-(vinyloxy)propane (CAS 109 -53 -5) to aquatic invertebrates was examined in a study according to OECD TG 202 and in compliance with GLP criteria (BASF, 2004). In this study, groups of daphnids (4 replicates of 5 animals) were exposed to the substance at nominal concentrations of 0 (control), 4.8, 9.5, 19, 38, 75, 150 and 300 mg/L in sealed vessels for 48 hours under static conditions. Nominal concentrations were analytically verified and recoveries ranged from ca. 98 to 177% at the start of the test and from ca. 88 to 150% after the 48 -hour exposure period. Mobility of exposed daphnids was recorded after 24 and 48 exposure. A 5% reduction of mobility was first seen at a nominal test concentration of 19 mg/L. At 38 mg/L immobility had increased to 10% and at higher tested concentrations immobility was 100%. Based on these findings, an 48 -h EC50 of 52.0 mg/L was determined (based on measured concentrations). After correction for difference in molecular weight between the read-across source and target substances, the 48 -h LC50 for 4-(vinyloxy)butan-1-ol is 60 mg/L.
A second test with daphnids was performed with 2 -(vinyloxy)ethanol (CAS 764 -48 -7) (BASF, 1999). In this study, which was performed according to OECD TG 202 and in compliance with GLP criteria, groups of daphnids (4 replicates of 5 animlas) were exposed to the substance at nominal concentrations of 0 (control), 12.5, 25, 50 and 100 mg/L for 48 hours under static conditions. Mobility of daphnids was recorded after 24 and 48 hour exposure. No significant immobility was seen in the test. The 48 -h EC50 was determined at >100 mg/L. Based on the log Kow of this substance, it is considered to have less potential for aquatic toxicity than 4 -(vinyloxy)butan-1 -ol and therefore this data is considered as supporting information only.
The 48 -h EC50 value of 60 mg/L from the study with 2-methyl-1-(vinyloxy)propane (CAS 109 -53 -5) is used for assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.