Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-653-7 | CAS number: 10294-26-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A reliable study available for acute oral toxicity of silver(I)sulfate is available (rat, LD50 > 5000 mg/kg bw). Similar acute oral toxicity studies with other silver substances, which all indicate low acute oral toxicity, are included in this dossier for comparative reasons.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-11-06 to 1990-11-28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Guideline study. At the time of the study conduct, GLP was not compulsory. However, the study was conducted in accordance with the principles of GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- , only two dose groups were used instead of three for reasons of animal welfare.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- other: Bor: WISW (SPFCpb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Versuchstierzucht GmbH & Co. KG., Borchen
- Age at study initiation: 8 - 9 weeks (males) and 9 - 10 weeks (females)
- Weight at study initiation: 147 - 209 g (males) and 135 - 159 g (females)
- Fasting period before study: 16 hours before treatment
- Housing: in Macrolon cages, type II, individually housing
- Diet: ad libitum (standard diet, ssniff R, special diet for rats)
- Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 22.5
- Humidity (%): 40 - 70
- Photoperiod: 12 hours dark/light cycle - Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 110 and 237 mg/mL
- Lot/batch no. (if required): 8249, supplied by H. Lamotte, Bremen
MAXIMUM DOSE VOLUME APPLIED: 21.5 mL/kg - Doses:
- 2370 mg/kg body weight
5110 mg/kg body weight - No. of animals per sex per dose:
- 5 maels and 5 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were continuously observed for the first 4 to 6 hours after administration and then once daily. The nature of the toxicity as well as the onset, the intensity and the duration of the signs were recorded.
Mortality was checked twice daily. Time of death and number of dead animals per dose were documented.
Body weights were recorded at the beginning and also 7 and 14 days after administration or after death of the animals on days 2 to 14.
- Necropsy of survivors performed: yes; at the end of the observation period the animals were sacrificed with C02
Gross necropsy: was performed on all animals. Macroscopical examination included external appearance, body orifices, body cavities (thoracic and abdominal), and their contents. - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- Deaths occurred on days 5 to 7 after administration.
Mortality rates, males:
2370 mg/kg body weight = 0%
5110 mg/kg body weight = 40% (2 animals died 5 and 7 days after exposure, respectively)
Mortality rates, females:
2370 mg/kg body weight = 0%
5110 mg/kg body weight = 40% (2 animals died 6 and 7 days after exposure, respectively) - Clinical signs:
- other: At a dose of 2370 mg/kg male and female animals performed diarrhea, black discoloured feces, and red nasal discharge. In male animals additionally chromodacryorrhea occurred. In one male and in one female animal each restrained gait or stilted gait, respe
- Gross pathology:
- At necropsy of deceased animals the stomach was tightly filled with food and the mucous membranes of glandular stomach, small and large intestine, or duodenum only were reddened. The whole intestine, cecum, or colon were filled with a discoloured fluid material. In one animal the stomach was tightly filled with white compacted material.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD 50 values were greater than 5000 mg/kg body weight (estimation) for male and female rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 5 000 mg/kg bw
- Quality of whole database:
- reliable and robust database
Additional information
Justification for classification or non-classification
A reliable study available for acute oral toxicity of silver(I)sulfate is available (rat, LD50 > 5000 mg/kg bw). Similar acute oral toxicity studies with other silver substances, which all indicate low acute oral toxicity, are included in this dossier for comparative reason.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.