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EC number: 248-273-7 | CAS number: 27157-94-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- FEB 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- GLP compliance:
- yes
- Remarks:
- Chemical analysis was not performed according to GLP
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Samples from the test concentrations 2-100 mg/L were analysed as they covered the concentrations causing 0-100 % effect.
- Sampling method: In order to verify the tested concentrations, samples were collected from the test solutions at the initiation of the test (t= 0 h) and at the termination of the test (t= 48 h).
- Sample storage conditions before analysis: Samples were stored at -20 ± 2.0 °C until analysis - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A stock solution of 100 mg/L were prepared by weighing out 100.1 mg of the test material and dissolving it in 1 L test medium. pH were adjusted to 8.0 in the stock solution. The test solutions were prepared by diluting the appropriate amounts of stock solution in the test medium. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: A strain of freshwater crustacean Daphnia magna Straus (Cladocera, Crustacea)
- age: less that 24 hours old
- Source: originally isolated from Langedam (Birkerød, Denmark), cultured at DHI since 1979. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20.1 ± 0.1 °C
- pH:
- 7.8-8.3
- Dissolved oxygen:
- 96-100 % saturation
- Nominal and measured concentrations:
- Nominal concentrations: 0 (control); 2.0; 5.0; 10; 20; 50 and 100 mg/L (based on test material)
The chemical analysis showed a measured Cresyl-P1 concentration of 113-116 % of the estimated nominal concentration. As the tested concentrations were maintained within ± 20 % of the nominal concentrations, the statistical calculation was made on the basis of the nominal concentrations. - Details on test conditions:
- TEST SYSTEM:
Static test in 50 mL glass beakers with 25 mL of test solution
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 6 - Reference substance (positive control):
- yes
- Remarks:
- 24-h acute toxicity test on the reference substance potassium dichromate (CAS No. 7778-50-9) was performed to check the sensitity of the test animals.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 19 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Remarks on result:
- other: 8.9-47 mg/L (95% confidence interval)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 29 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 14-74 mg/L (95% confidence interval)
- Results with reference substance (positive control):
- 24-h EC50 = 1.6 (1.4-1.7) mg/L, which is witin the range specified in the ISO 6341 guideline (0.6-2.1 mg/L).
- Validity criteria fulfilled:
- yes
- Remarks:
- < 10 % of control animals were immobilized. Dissolved oxygen saturation at the end was ≥ 96% in both tests and controls. EC50(24h) = 1.6 mg/L for control substance (K2Cr2O7, CAS no 7778-50-9) which in the specified range (0.6-2.1 mg/L)
- Conclusions:
- The 48-hour EC50 was calculated to be 19 mg/L (nominal).
- Executive summary:
An acute toxicity test with the crustacean Daphnia magna was conducted according to OECD Guideline 202 under GLP compliance. After 48 hour exposure the immobility was recorded. The 48 h EC50 for test item was observed to be 19 mg/L (nominal).
Reference
Description of key information
An acute toxicity test with the crustacean Daphnia magna was conducted according to OECD Guideline 202 under GLP compliance. After 48 hour exposure the immobility was recorded. The 48 h EC50 for test item was observed to be 19 mg/L (nominal).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 19 mg/L
Additional information
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