Registration Dossier
Registration Dossier
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EC number: 209-842-5 | CAS number: 594-44-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- not specified
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data from Handbook or collection of data with no details
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- No information
- Author:
- Bingham, E.; Cohrssen, B.; Powell, C.H.
- Year:
- 2 001
- Bibliographic source:
- Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 7:747
Materials and methods
Test material
- Reference substance name:
- Ethanesulphonyl chloride
- EC Number:
- 209-842-5
- EC Name:
- Ethanesulphonyl chloride
- Cas Number:
- 594-44-5
- Molecular formula:
- C2H5ClO2S
- IUPAC Name:
- ethanesulfonyl chloride
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Duration of exposure:
- 4 h
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- 86 ppm
- Mortality:
- All rats died within 30 to 130 min during an exposure to 1273 ppm.
- Clinical signs:
- other: Eye irritation, lacrimation, salivation, and gasping.
- Gross pathology:
- Decedents exhibited pulmonary hemorrhage
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information
- Conclusions:
- Acute (4-hr) inhalation studies indicated an LC50 of approximately 86 ppm (equivalent to 0.45 mg/L) in the rat. The substance is classified into the toxicity category II.
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