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EC number: 239-888-1 | CAS number: 15790-07-5 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 15985:1.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Data is from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute Dermal Toxicity of Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex (CAS No. – 15790-07-5) in Wistar Albino Rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex
- EC Number:
- 239-888-1
- EC Name:
- Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex
- Cas Number:
- 15790-07-5
- Molecular formula:
- C16H9AlN2O7S2
- IUPAC Name:
- aluminium(3+) 6-sulfonato-1-[(1E)-2-(4-sulfonatophenyl)diazen-1-yl]naphthalen-2-olate
- Details on test material:
- Name - Aluminium, 6-hydroxy-5-{(4-sulfophenyl) azo}-2-Naphthalenesulfonic acid complex
InChI - 1S/C16H12N2O7S2.Al/c19-15-8-1-10-9-13(27(23,24)25)6-7-14(10)16(15)18-17-11-2-4-12(5-3-11)
26(20,21)22;/h1-9,19H,(H,20,21,22)(H,23,24,25);/q;+3/p-3/b18-17+;
Smiles - c12c(cc(S(=O)(=O)[O-])cc2)ccc(c1\N=N\c1ccc(S(=O)(=O)[O-])cc1)[O-].[Al+3]
Mol. formula: C16H9AlN2O7S2
Molecular Weight - 432.368 g/mole
Constituent 1
- Specific details on test material used for the study:
- Name - Aluminium, 6-hydroxy-5-{(4-sulfophenyl) azo}-2-Naphthalenesulfonic acid complex
InChI - 1S/C16H12N2O7S2.Al/c19-15-8-1-10-9-13(27(23,24)25)6-7-14(10)16(15)18-17-11-2-4-12(5-3-11)
26(20,21)22;/h1-9,19H,(H,20,21,22)(H,23,24,25);/q;+3/p-3/b18-17+;
Smiles - c12c(cc(S(=O)(=O)[O-])cc2)ccc(c1\N=N\c1ccc(S(=O)(=O)[O-])cc1)[O-].[Al+3]
Mol. formula: C16H9AlN2O7S2
Molecular Weight - 432.368 g/mole
Characteristics : Orange yellow powder
Source: Unique Chemicals & Allied Products
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Institute for Industrial Research & Toxicology, Ghaziabad
- Females (if applicable) nulliparous and non-pregnant: No
- Age at study initiation: 8 to 10 weeks
- Weight at study initiation: 200±20g
- Fasting period before study: No data
- Housing:Groups of 2 animals of similar sex in polypropylene cages with stainless steel grill top, facilities for food and water bottle, and bedding of clean paddy husk.
- Diet (e.g. ad libitum): Pelleted feed
- Water (e.g. ad libitum): Fresh and clean water filered through 'Aqua Guard on line water filter', was kept in glass bottles, ad libitum
- Acclimation period: The healthy Wistar albino rats selected for study accliatized to standard laboratory condition for period of one week under close veterinary supervision.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): temperature between 22-25°C
- Humidity (%): relative humidity 40-60%
- Air changes (per hr): 10-15 air changes per hour
- Photoperiod (hrs dark / hrs light): illumination cycle set to 12 hours artificial fluorescent light and 12
hours dark.
IN-LIFE DATES: From:18/03/2013 To:28/04/2013
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back skin of total body surface area
- % coverage: 10%
- Type of wrap if used: The test compound held in contact with an impervious dressing secured in place with an adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The dressing was removed and the site of application was cleaned with lukewarm water wiping the test compound.
- Time after start of exposure: 24 Hours - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- Total = 20
Group I - 2000 mg/kg - 10 (5 male and Female)
Group II - 2000 mg/kg - 10 (5 male and Female) - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:The body weight of all the animals was observed weekly on day 0 (pre treatment), 7th and 14th (post treatment).Rats were observed for mortality at 30 minutes time interval for first 6 hous on the day of test compund and therafter twice a day for 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: The treated animals were closely observed for clinical signs of in toxication, first 4 hours and every 1 hrs interval for 24 hrs after dosing and thereafter twice a day for 14 days. All the rats were observed at least twice daily with the purpose of recording any symptoms of ill-health or behavioral changes. The organ which showed gross pathological change during necropsy subjected for histopathological study. - Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 2000 mg/kg bw
- Clinical signs:
- other: Animals did not produce any clinical signs of intoxication throughout the period of observation.
- Gross pathology:
- No significant gross pathological changes related to compound toxicity were observed.
- Other findings:
- Skin and hair coat was observed wet.
Any other information on results incl. tables
TABLE – 2
SUMMARY OF BODY WEIGHT (GM)
Group |
Animal ID |
Day 0 |
Day 7 |
% Gain/loss |
Day 14 |
% Gain/loss |
Group-I 2000 mg/kg b. wt |
201303-1 |
203.5 |
208.7 |
2.56 |
215.5 |
5.90 |
201303-2 |
202.6 |
209.3 |
3.30 |
215.8 |
6.51 |
|
201303-3 |
201.8 |
207.9 |
3.02 |
214.0 |
6.05 |
|
201303-4 |
204.2 |
210.4 |
3.04 |
217.2 |
8.13 |
|
201303-5 |
201.5 |
209.6 |
4.01 |
217.9 |
8.13 |
|
201303-6 |
201.6 |
208.3 |
3.32 |
216.8 |
7.54 |
|
201303-7 |
200.9 |
207.5 |
3.28 |
213.3 |
6.17 |
|
201303-8 |
200.2 |
207.1 |
3.45 |
216.5 |
8.14 |
|
201303-9 |
199.5 |
206.3 |
3.40 |
210.2 |
5.36 |
|
201303-10 |
201.7 |
209.6 |
3.92 |
217.7 |
7.93 |
|
Group-III 2000 mg/kg b. wt |
201303-11 |
199.8 |
207.3 |
3.75 |
214.3 |
7.25 |
201303-12 |
201.5 |
208.8 |
3.62 |
213.1 |
5.75 |
|
201303-13 |
198.8 |
206.5 |
3.87 |
214.6 |
7.95 |
|
201303-14 |
200 |
206.6 |
3.30 |
213.9 |
6.95 |
|
201303-15 |
203.5 |
209.2 |
2.80 |
216.4 |
6.34 |
|
201303-16 |
203.2 |
211.4 |
4.03 |
217.3 |
6.93 |
|
201303-17 |
201.3 |
208.4 |
3.52 |
216.7 |
7.65 |
|
201303-18 |
202.3 |
210.1 |
3.36 |
216.2 |
7.37 |
|
201303-19 |
200 |
206.6 |
3.30 |
214.2 |
7.10 |
|
201303-20 |
204.1 |
210.6 |
3.19 |
217.5 |
6.57 |
TABLE – 3
CLINICAL SIGNS AND MORTALITY
Group: I Limit Test Dose: 2000 mg/kg body weight
Parameters |
Incidence of clinical signs observed after dosing |
Mortality |
|||||||||||||||||||
Day 0 |
DAY |
||||||||||||||||||||
Min |
Hour |
||||||||||||||||||||
30 |
1 |
2 |
4 |
6 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
Total* |
% |
|
Mortality (total) |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/10 |
0 |
Clinical Signs - Local |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
Redness |
- |
- |
- |
- |
- |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
Pain |
- |
- |
- |
- |
- |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
Swelling |
- |
- |
- |
- |
- |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
Systemic signs |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- = Observed after 24 hrs
0 = No clinical sign (Normal)
+ = Mild
++ = Moderate
+++ = High
++++ = Severe
TABLE – 3 Contd….
CLINICAL SIGNS AND MORTALITY
Group: II Confirmatory Test Dose: 2000 mg/kg body weight
Parameters |
Incidence of clinical signs observed after dosing |
Mortality |
|||||||||||||||||||
Day 0 |
DAY |
||||||||||||||||||||
Min |
Hour |
||||||||||||||||||||
30 |
1 |
2 |
4 |
6 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
12 |
13 |
14 |
Total* |
% |
|
Mortality (total) |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0/10 |
0 |
Clinical Signs - Local |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
Redness |
- |
- |
- |
- |
- |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
Pain |
- |
- |
- |
- |
- |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
Swelling |
- |
- |
- |
- |
- |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
Systemic signs |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
- = Observed after 24 hrs
0 = No clinical sign (Normal)
+ = Mild
++ = Moderate
+++ = High
++++ = Severe
TABLE – 4
SUMMARY OF NECROPSY FINDINGS
S. No. |
Fate
|
Wistar albino rats |
|
Dose (mg/kg b. wt) |
|||
2000 (Limit Test)
|
2000 (Confirmatory Test)
|
||
1 |
Terminal sacrifice |
10/10 |
10/10 |
2 |
Found Dead |
0/10 |
0/10 |
3 |
Abnormalities detected |
0/10 |
0/10 |
TABLE - 5
INDIVIDUAL ANIMAL FATE & NECROPSY FINDINGS
Group: I (Limit Test) Dose: 2000 mg/kg bw |
|||
Animal ID |
Fate |
Time |
Gross Findings |
201303-1 |
TS |
Day 15 |
NAD |
201303-2 |
TS |
Day 15 |
NAD |
201303-3 |
TS |
Day 15 |
NAD |
201303-4 |
TS |
Day 15 |
NAD |
201303-5 |
TS |
Day 15 |
NAD |
201303-6 |
TS |
Day 15 |
NAD |
201303-7 |
TS |
Day 15 |
NAD |
201303-8 |
TS |
Day 15 |
NAD |
201303-9 |
TS |
Day 15 |
NAD |
201303-10 |
TS |
Day 15 |
NAD |
Group: I (Limit Test)Dose: 2000 mg/kg bw |
|||
201303-11 |
TS |
Day 15 |
NAD |
201303-12 |
TS |
Day 15 |
NAD |
201303-13 |
TS |
Day 15 |
NAD |
201303-14 |
TS |
Day 15 |
NAD |
201303-15 |
TS |
Day 15 |
NAD |
201303-16 |
TS |
Day 15 |
NAD |
201303-17 |
TS |
Day 15 |
NAD |
201303-18 |
TS |
Day 15 |
NAD |
201303-19 |
TS |
Day 15 |
NAD |
201303-20 |
TS |
Day 15 |
NAD |
Day 0 is the day of dose administration.
TS- Terminal Sacrifice
NAD- No abnormality Detected
FD – Found dead
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute dermal LD50 of Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex (CAS No. - 15790-07-5) was >2000 mg/kg body weight. Thus, it was concluded that the acute toxicity study of Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex, when applied by dermal route in wistar albino rats falls into the “Category 5 (>2000) by Harmonized Classification (GHC).
- Executive summary:
The study now reported was designed and conducted to determine the acute dermal toxicity profile of Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex (CAS No. 15790-07-5) in wistar albino rats. The study was conducted under the OECD Guideline-402 for testing of chemicals. In limit test, healthy wistar albino rats of body weight 200±20 gm were selected for study after acclimatization. Approximate 10% back skin of total body surface area was prepared 24 hrs prior to application of test compound. Test drug was applied dermally at the dose of 2000 mg/kg bw for each animal. The treated animals were observed for clinical signs of intoxication.The body weight of all the animals was observed weekly on day 0 (pre treatment), 7th and 14th (post treatment). The Necropsy was performed on all at the termination of the study. After 72 hrs, a confirmatory test was conducted in same species of animals to confirm the limit test of the test compound. Rats were observed for mortality at 30 minutes time interval for first 6 hous on the day of test compund and therafter twice a day for 14 days.All the rats were observed at least twice daily with the purpose of recording any symptoms of ill-health or behavioral changes. The organ which showed gross pathological change during necropsy subjected for histopathological study.No mortality was observed at 2000 mg/kg bw. Animals did not produce any clinical signs of intoxication throughout the period of observation.Animals showed normal gain in body weight on day 7th and 14th as compared to control group.No significant gross pathological changes related to compound toxicity were observed.Skin and hair coat was observed wet. Therefore, it was concluded that the test compoundAluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex (CAS No. 15790-07-5)is non-toxic at the tested dose level 2000 mg/kg body weight. According to Globally Harmonized Classification System for Chemical Substances, it comes under the Globally Harmonized Classification (GHC) Category-5 (>2000).
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