Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Study period:
09/1964
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
Farbenfabrik Bayer AG
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclododecanol
EC Number:
217-031-2
EC Name:
Cyclododecanol
Cas Number:
1724-39-6
Molecular formula:
C12H24O
IUPAC Name:
cyclododecanol
Details on test material:
TS: "pure" cyclododecanol, no further information

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no details

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: acetone and vegetable oil 1:10
Details on exposure:
ADMINISTRATION: 
- Volume administered or concentration: 5 ml/kg bw
Doses:
250; 500; 1000; 1250; 1500; 2000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Post dose observation period: 7 days
Statistics:
LD50 calculation: according to LICHTFIELD and WILCOXON

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 230 mg/kg bw
Mortality:
MORTALITY: 
- Time of death: within 1-3 days
details see below
Clinical signs:
CLINICAL SIGNS: 
All dosed animals except those in the 250 mg/kg bw group  showed clinical signs: difficult breathing, narcosis, tremor.
Body weight:
no data
Gross pathology:
no data
Other findings:
no other findings

Any other information on results incl. tables

Mortality

- Number of deaths at each dose: 
   250 mg/kg bw: no deaths
   500 mg/kg bw: no deaths
  1000 mg/kg bw: 2/10 animals died
  1250 mg/kg bw: 5/10 animals died
  1500 mg/kg bw: 8/10 animals died
  2000 mg/kg bw: 10/10 animals died
  LD50 = 1230 (1090-1390) mg/kg bw

Applicant's summary and conclusion

Conclusions:
Under the conditions of this study the LD 50 for acute intraperitoneale toxicity of Cyclododecanol is determined to be 1230 mg/kg of body weight in rats.
Executive summary:

The test item Cyclododecanol was applied intraperitoneale once to 6 dose-groups of 10 rats in doses of 250, 500, 1000, 1250, 1500 and 2000 mg/kg bw as solution in acetone/vegetable oil 1:10. The dose groups from 500 mg/kg showed mortality. No clinical signs were observed in the 250 mg/kg bw  group, but all animals that received higher doses showed symptoms:   difficult breathing, narcosis, tremor.

Under the conditions of this study the LD 50 for acute intraperotoneale toxicity of Cyclododecanol is determined to be 1230 mg/kg of body weight in rats.