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EC number: 425-660-0 | CAS number: 165101-57-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2005-04-07 to 2005-04-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- adopted 31.07.1992
- Deviations:
- yes
- Remarks:
- A modified version of Method C7 was performed, as the test material degraded almost instantly in aqueous media.
- Principles of method if other than guideline:
- A modified version of Method C7 was performed, as the test material degraded almost instantly in aqueous media. The test was designed to illustrate the instability of the test material, whilst utilising a test temperature at which the rate of reaction was slow enough to observe some test material in the initial samples.
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- An aliquot (200 mL) of each sample was extracted with three portions (2 x 25 mL) of dichloromethane, each extract being filtered through anhydrous sodium sulphate. The combined extracts were evaporated to dryness and the residue re-dissolved in methanol (2 mL). This was performed in duplicate for each time-point taken.
Aliquots of the sample solutions were taken initially and after 4 hours, and the pH of each solution recorded. - Buffers:
- Buffer solutions
- pH: 4
- Composition and molarity: Potassium hydrogen phthalate, 12.5 mmol
- pH: 7
- Composition and molarity: Disodium hydrogen orthophosphate (anhydrous) 7.5 mmol; Potassium dihydrogen orthophosphate 5.0 mmol; Sodium chloride 5.0 mmol
- pH: 9
- Composition and molarity: Disodium tetraborate 2.5; Sodium chloride 5.0 mmol - Details on test conditions:
- Preparation of the buffer solutions
The buffer solutions were filtered through a 0.2 µm membrane filters to ensure they were sterile before commencement of the test. Also these solutions were subjected to ultrasonication and degassing with nitrogen to minimise dissolved oxygen content.
Preparation of samples
Sample solutions were prepared at a nominal concentration of 20 mg/L in the three buffer solutions and split into separate glass flasks for each time-point. A 1 % co-solvent of acetonitrile was used to aid solubility. A nitrogen headspace was used to prevent volatilisation.
The solutions were shielded from light whilst maintained at the test temperature.
Test 1
Sample solutions at pH 4, 7 and 9 were maintained at 10.0 ± 0.5 °C for a period of 4 hours.
Analysis of sample solutions
Aliquots of the sample solutions were taken initially and after 4 hours, and the pH of each solution recorded. The concentration of the sample solution was determined by gas chromatography. - Number of replicates:
- 2 (duplicates)
- Transformation products:
- no
- % Recovery:
- 8.89
- pH:
- 4
- Temp.:
- 10 °C
- Duration:
- 0 h
- % Recovery:
- < 1.17
- pH:
- 4
- Temp.:
- 10 °C
- Duration:
- 4 h
- % Recovery:
- 3.14
- pH:
- 7
- Temp.:
- 10 °C
- Duration:
- 0 h
- % Recovery:
- < 0.71
- pH:
- 7
- Temp.:
- 10 °C
- Duration:
- 4 h
- % Recovery:
- 1.84
- pH:
- 9
- Temp.:
- 10 °C
- Duration:
- 0 h
- % Recovery:
- 0.978
- pH:
- 9
- Temp.:
- 10 °C
- Duration:
- 4 h
- Key result
- pH:
- 4
- Temp.:
- 10 °C
- DT50:
- < 4 h
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 10 °C
- DT50:
- < 4 h
- Type:
- not specified
- Key result
- pH:
- 9
- Temp.:
- 10 °C
- DT50:
- < 4 h
- Type:
- not specified
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test material was shown to hydrolyse on contact with aqueous media. The respective half-lives of the test item in the prepared buffer solutions (pH 4, pH 7, pH 9) at 10°C were below 4 hours.
- Executive summary:
An assessment of the hydrolytic stability of the test material was performed in accordance with EU method C.7. The test item was prepared at a nominal concentration of 20 mg/L in three buffer solutions with varying pH values (pH 4, pH 7 and pH 9). The solutions were maintained at 10 °C for a period of 4 hours. To determine the hydrolytic stability, aliquots of the sample solutions were taken initially and after 4 hours and the residual concentration of the test item was determined by gas chromatography.
The following results were obtained:
- At a pH of 4 less than 1.17 % of the test material was remaining after 4 hours.
- At a pH of 7 less than 0.710 % of the test material was remaining after 4 hours.
- At a pH of 9 less than 0.978 % of the test material was remaining after 4 hours.
In conclusion, all the respective half-lives of the test item in the prepared buffer solutions were below 4 hours. Therefore, the test material was shown to hydrolyse on contact with aqueous media.
Reference
Description of key information
The test material was shown to hydrolyse on contact with aqueous media. The respective half-lives of the test item in the prepared buffer solutions (pH 4, pH 7, pH 9) at 10 °C were below 4 hours.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 4 h
- at the temperature of:
- 10 °C
Additional information
An assessment of the hydrolytic stability of the test material was performed in accordance with EU method C.7. The test item was prepared at a nominal concentration of 20 mg/L in three buffer solutions with varying pH values (pH 4, pH 7 and pH 9). The solutions were maintained at 10 °C for a period of 4 hours. To determine the hydrolytic stability, aliquots of the sample solutions were taken initially and after 4 hours and the residual concentration of the test item was determined by gas chromatography.
The following results were obtained:
- At a pH of 4 less than 1.17 % of the test material was remaining after 4 hours.
- At a pH of 7 less than 0.71 % of the test material was remaining after 4 hours.
- At a pH of 9 less than 0.978 % of the test material was remaining after 4 hours.
In conclusion, all the respective half-lives of the test item in the prepared buffer solution were below 4 hours. Therefore, the test material was shown to hydrolyse on contact with aqueous media.
The key value for the chemical safety assessment was set at a hydrolysis half-life of 4 h in order to obtain a numerical figure to allow for CSA calculations. However, it must be highlighted that this value is based on a very worst case scenario and does not truly reflect the results obtained from this study where the actual half-life determined was considerably less than 4 h.
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