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EC number: 209-750-5 | CAS number: 592-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound butyl chloroformate (CAS 592-34-7, rapidly hydrolyzing): Acutely harmful to fish.
Hydrolysis product hydrogen chloride (HCL, CAS 7647 -01 -0): Acutely toxic to fish (pH dependent).
Hydrolysis product butanol (CAS 71 -36 -3): With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 4.64 mg/L
Additional information
Data for parent compound butyl chloroformate (CAS 592-34-7):
Data on the acute toxicity of butyl chloroformate (CAS 592-34-7) to fish are available from a study performed according to DIN 38412 (L1 and L15). L. idus was used as test organism. The 96 -h LC50 value was determined to be ca. 4.64 mg/L (nominal; BASF AG, 1988).
However, the substance rapidly hydrolyses in contact with water to butanol (CAS 71 -36 -3), hydrogen chloride (HCL, CAS 7647 -01 -0) and carbon dioxide (CAS 124-38-9). The assessment is, therefore, additionally based on the available data of the hydrolysis products.
Data for Hydrolysis product - hydrogen chloride (HCL, CAS 7647-01-0):
For the hydrolysis product hydrogen chloride (HCL, CAS 7647-01-0) a short-term study with fish (C. carpio) according to OECD guideline 203 is available (OECD SIDS, 2002). The 96-h LC50 value was determined to be 4.92 mg/L (acid equivalent converted from pH 4.3).
Hydrolysis product – butanol (CAS 71-36-3):
For the hydrolysis product butanol (CAS 71-36-3) a number of results from fish studies are available. The key effect value is a 96 -h LC50 > 100 mg/L as observed in a study with O. latipes. The study was conducted according to OECD guideline 203 and in compliance with GLP criteria and the test concentrations were analytically verified (NITE, 1992). Another key study followed with OECD 204 guideline showed the 14-d LC50 to be 85 mg/L (analytically verified, NITE, 1984). In addition, several acute ecotoxicity studies with fish (Fathead minnow, Bleak) are also available for CAS 71-36-3. According to these supporting data the lowest effect LC50 value was 1376 mg/L (96 h, analytically verified, OECD 201, SIDS 2001).
For the hydrolysis product carbon dioxide, no fish toxicity data are available.
Assessment:
In the study with the parent substance butyl chloroformate (CAS 592-34-7; BASF AG, 1988), all observed mortality occurred between 1 to 24 hours after the start of the exposure period. However, the substance rapidly hydrolyses in contact with water to butanol (CAS 71-36-3), hydrogen chloride (HCL, CAS 7647-01-0) and carbon dioxide (CAS 124-38-9). Furthermore, the observed effect values from studies with the hydrolysis product butanol (CAS 71-36-3) are much higher than the effect values determined for the parent compound. Therefore, the observed toxicity in the study with butyl chloroformate (CAS 592-34-7) itself is considered to be related to the high reactivity of unhydrolyzed butyl chloroformate at the beginning of the test rather than to exposure to the hydrolysis product butanol. Additionally, the the obsereved toxic effects are considered to be not due to pH caused by the hydrolysis product HCl (CAS 7647 -01 -0) as the pH of the test solutions remained close to the pH of the control solutions.
Summary of acute fish toxicity data:
Compound |
Species |
Results |
Guideline |
Reference |
Parent Compound (CAS 592-34-7) |
Leuciscus idus |
96-h LC50 = ca. 4.64 mg/L |
DIN 38412 L15 |
BASF AG (1988) |
Hydrolysis product (CAS 7647-01-0) |
Cyprinus carpio |
96-h LC50 = 4.92 mg/L (pH-dependent; acid equivalent) |
OECD 203 |
OECD SIDS (2002) |
Hydrolysis product (CAS 71-36-3) |
Oryzias latipes |
96-h LC50 ≥ 100 mg/L |
OECD 203 |
MOE, Japan (1996) |
Hydrolysis product (CAS 71-36-3) |
Oryzias latipes |
14-d LC50 = 85 mg/L 7-d LC50 ≥ 100 mg/L |
OECD 204 |
MOE, Japan (1996) |
Hydrolysis product (CAS 71-36-3) |
div. |
96-h LC50 >1000 mg/L |
div. |
OECD SIDS (2001); (summary of div. test results) |
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