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EC number: 204-875-1 | CAS number: 128-03-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Experimental data from tests investigating the toxicity of KDDC to terrestrial organisms were not conducted since studies from similar analogues are considered suitable for this purpose in accordance with the specifications listed in Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances and read across, on basis of structural similarity, physico-chemical properties, ecotoxicological profiles. There is no convincing evidence that any one of these chemicals might lie out of the overall profile of this analogue approach, respectively. Conclusions regarding this section were drawn based on studies performed on SDDC (sodium dimethyldithiocarbamate, CAS No. 128-04-1) and Ziram (zinc bis(dimethyldithiocarbamate), CAS No. 137-30-4). KDDC, SDDC and Ziram represent salts of dimethyl dithiocarbamic acid (DDC) that are capable of dissociating into the respective ions when exposed to water. The main differences between Ziram and KDDC/SDDC are the solubility in water and partition coefficient related to the rather covalent character of the zinc-sulphur bond with respect to the sodium-sulphur bond. The physico-chemical parameters of the three substances are listed in the table below.
Table 2. Physico-chemical parameters of KDDC, SDDC and Ziram
Parameter |
KDDC |
SDDC |
Ziram* |
Molecular weight |
159.3 g/mol |
143.2 g/mol |
305.8 g/mol |
Melting point |
Partial melting from 81.5 to 85.0°C followed by slow decomposition |
Decomposition at |
251.0 – 252.5°C |
Relative density at 20°C |
1.51 |
1.4 |
1.7097 |
Vapour pressure at 25°C |
8.76×10-5Pa |
< 2×10–4Pa |
1.8×10–5Pa |
Log Pow at 20°C |
read across to SDDC |
pH 5: = –3.2 |
1.65 pH range: 7.4-8.6[1] |
Water solubility |
read across to SDDC |
37.4 - 40% (w/w) |
9.67×10–4g/L |
*data are not presented within this dossier, but where subject to the respective REACh-registration of Ziram (CAS: 137-30-4, EC: 205-288-3)
An acute earthworm study is available for the analogue showing the highest resemblance to KDDC, i.e. SDDC. The remaining terrestrial endpoints were covered by data of Ziram. This approach can be considered as a worst-case scenario, since the comparison between SDDC and Ziram in a) aquatic toxicity tests (see technical dossier chapter 6.1) and b) for the terrestrial compartment (in acute earthworm studies),showed significantly lower effect concentrations for Ziram than those for SDDC (LC50(14d) = 140 mg a.i./kg soil (dw)* for Ziram and LC50(14d) = 787.6 mg a.i./kg soil (dw) for SDDC, respectively).
Based on the results from the studies performed on the analogue substances, KDDC may cause toxic effects to some terrestrial organisms (e.g. Eisenia fetida: NOEC of 4.053 mg a.i./kg dw soil).
The table below summarizes the effects of the analogue substances Ziram and SDDC to terrestrial organisms:
Table 4. Ecotoxicological data of SDDC and Ziram in the terrestrial compartment
Endpoint |
Test duration |
Effect value |
Substance |
Toxicity to soil macroorganisms except arthropods |
14d |
LC50 = 787.6 mg a.i./kg soil d.w. |
SDDC |
Toxicity to soil macroorganisms except arthropods |
56d |
NOEC = 4.053 mg a.i./kg soil d.w. |
Ziram |
Toxicity to terrestrial arthropods |
48 h |
LD50 > 100 µg per animal |
Ziram |
Toxicity to terrestrial plants |
21 d |
NOEC = 9 kg/ha |
Ziram |
Toxicity to soil microorganisms |
56d |
NOEC = 40 kg/ha |
Ziram |
Toxicity to birds |
14 d |
LD50 = 97 mg /kg bw |
Ziram |
Toxicity to birds |
5 d |
LC50 = 5156 mg/kg diet |
Ziram |
Toxicity to birds |
20 wk |
NOEC > 500 mg/kg diet |
Ziram |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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