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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: poisoning incident
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles

Data source

Reference
Reference Type:
publication
Title:
Perorale Intoxikation mit Isocyanat und Methylenchlorid
Author:
Bernoulli et al.
Year:
1978
Bibliographic source:
Schweiz. med. Wschr. 108, 866-868

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
acute toxicity: oral
Test guideline
Qualifier:
no guideline available

Test material

Constituent 1
Chemical structure
Reference substance name:
Methylidynetri-p-phenylene triisocyanate
EC Number:
219-351-8
EC Name:
Methylidynetri-p-phenylene triisocyanate
Cas Number:
2422-91-5
Molecular formula:
C22H13N3O3
IUPAC Name:
1-[bis(4-isocyanatophenyl)methyl]-4-isocyanatobenzene

Method

Subjects:
- Number of subjects exposed: one
- Sex: male
- Age: 44
- Known diseases: depression, gastric resection according to Billroth II
Route of exposure:
oral
Reason of exposure:
other: suicide attempt
Exposure assessment:
estimated

Results and discussion

Clinical signs:
Coma, shock, relative bradycardia, leukocytosis and metabolic acidosis (were ascribed to the effect of methylene chloride)

Applicant's summary and conclusion