Registration Dossier
Registration Dossier
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EC number: 219-351-8 | CAS number: 2422-91-5
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: poisoning incident
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Perorale Intoxikation mit Isocyanat und Methylenchlorid
- Author:
- Bernoulli et al.
- Year:
- 1 978
- Bibliographic source:
- Schweiz. med. Wschr. 108, 866-868
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline available
Test material
- Reference substance name:
- Methylidynetri-p-phenylene triisocyanate
- EC Number:
- 219-351-8
- EC Name:
- Methylidynetri-p-phenylene triisocyanate
- Cas Number:
- 2422-91-5
- Molecular formula:
- C22H13N3O3
- IUPAC Name:
- 1-[bis(4-isocyanatophenyl)methyl]-4-isocyanatobenzene
Constituent 1
Method
- Subjects:
- - Number of subjects exposed: one
- Sex: male
- Age: 44
- Known diseases: depression, gastric resection according to Billroth II - Route of exposure:
- oral
- Reason of exposure:
- other: suicide attempt
- Exposure assessment:
- estimated
Results and discussion
- Clinical signs:
- Coma, shock, relative bradycardia, leukocytosis and metabolic acidosis (were ascribed to the effect of methylene chloride)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
