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EC number: 267-008-6 | CAS number: 67762-27-0 This substance is identified by SDA Substance Name: C16-C18 alkyl alcohol and SDA Reporting Number: 19-060-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Alcohols, C16-18 is a member and is from Long Chain Alcohols (C6-22 primary aliphatic alcohols) category.
The Long Chain Alcohols (C6-22 primary aliphatic alcohols) category is considered suitable as a source of data for Alcohols, C16-18.
Considered valid for read-across for purposes of classification.
No further vertebrate testing can be justified.
Long Chain Alcohols (C6-22 primary aliphatic alcohols) category covers a family of 30 primary aliphatic alcohols within a carbon chain length range of C6-C22. Commercial products generally include several aliphatic alcohol components, with a range of carbon chain lengths present. The family consists of alcohols with varying compositions and structures. Composition depends on the route to manufacture and the related feedstocks. Most of the alcohols have linear carbon chains but certain manufacturing processes create branched structures. Data are also available for eleven other similar substances, which support the category. Non-sponsored alcohols may not be HPV or may not be produced by members of the consortium, but have structures similar to sponsored linear alcohols.
Key points are that the members share:
• The same structural features
• Similar metabolic pathways
• Common mode of ecotoxicological action
• Common levels and mode of human health related effects. - Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- the test substance was not determined in solution
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- yes
- Remarks:
- the test substance was not determined in solution
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 40 mg of test substance was dissolved in 10 ml of vehicle with the aid of ultrasonic disruption. An aliquot (2 ml) of this stock solution was dispersed in 20 L of dechlorinated tap water to give the test concentration of 0.4 mg/L.
- Chemical name of vehicle: tetrahydrofuran
- Concentration of vehicle in test medium: 10 ml final volume in stock solution (equivalent to 0.1 ml in test medium). - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: rainbow trout
- Source: Donnington Fish Farm, Upper Swell, Gloucestershire, UK
- Length at study initiation (mean and SD): 4.5 cm (s.d = 0.2) at the end of the definitive study
- Weight at study initiation (mean and SD): 1.20 g (s.d = 0.26) at the end of the definitive study
- Feeding during test: feeding was discontinued 24 h prior to test initiation and they were not fed during the test
ACCLIMATION
- Acclimation period: from 26th Feb 1996 to 4th March 1996
- Acclimation conditions: test conditions
- Type and amount of food: commercial trout pellets
- Health during acclimation (any mortality observed): 2% - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none reported
- Hardness:
- 136 CaCO3 mg/L
- Test temperature:
- 13-14 ºC
- pH:
- range: 7.5-7.9
- Dissolved oxygen:
- >= 9.7 mg/L
- Salinity:
- Not Applicable
- Nominal and measured concentrations:
- Nominal concentration: 0.4 mg/L
- Details on test conditions:
TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): covered to reduce evaporation
- Material, size, headspace, fill volume: 20 L glass vessels
- Renewal rate of test solution (frequency): daily
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.6 mg body weight/L (static volume)
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tap water (by passage through an activated carbon filter)
- Metals: 70 ug/L or less
- Chlorine: 0.22 mg/L
- Alkalinity: 80 mg/L as CaCO3
- Ca/mg ratio: ca. 6:1
- Conductivity: 382 MICSM
- Culture medium different from test medium: same water
- Intervals of water quality measurement: 0, 24, 48, 72 and 96 h
OTHER TEST CONDITIONS
- Photoperiod: 16 h light, 8 h darkness
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : at 3, 6, 24, 48, 72 and 96 h fish were monitored for mortality and adverse effects (mortality and behaviour).
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1 test concentrations used
- Justification for using less concentrations than requested by guideline: limit test
- Range finding study
- Test concentrations: 0.04 and 0.4 mg/L
- Results used to determine the conditions for the definitive study: LC50 >0.4 mg/L- Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: non-toxic at the limit of solubility
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: non-toxic at the limit of solubility
- Details on results:
- - Mortality of control: 0%
- Effect concentrations exceeding solubility of substance in test medium: The solubility of octadecanol is 0.0011 mg/L at 25oC - Validity criteria fulfilled:
- yes
- Conclusions:
- A 96 h LC50 value of >0.4 mg/L was determined for the effect of the test substance on mortality of the fish O. mykiss. The water solubility of octadecanol is 0.0011 mg/L at 25oC , therefore the LC50 value is >0.0011 mg/L, The water solubility of octadecanol is 0.0011 mg/L at 25oC, therefore the LC50 value is >0.0011 mg/L (>LoS), i.e. the test substance was not toxic at the LoS.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Alcohols, C16-18 is a member and is from Long Chain Alcohols (C6-22 primary aliphatic alcohols) category.
The Long Chain Alcohols (C6-22 primary aliphatic alcohols) category is considered suitable as a source of data for Alcohols, C16-18.
Considered valid for read-across for purposes of classification.
No further vertebrate testing can be justified.
Long Chain Alcohols (C6-22 primary aliphatic alcohols) category covers a family of 30 primary aliphatic alcohols within a carbon chain length range of C6-C22. Commercial products generally include several aliphatic alcohol components, with a range of carbon chain lengths present. The family consists of alcohols with varying compositions and structures. Composition depends on the route to manufacture and the related feedstocks. Most of the alcohols have linear carbon chains but certain manufacturing processes create branched structures. Data are also available for eleven other similar substances, which support the category. Non-sponsored alcohols may not be HPV or may not be produced by members of the consortium, but have structures similar to sponsored linear alcohols.
Key points are that the members share:
• The same structural features
• Similar metabolic pathways
• Common mode of ecotoxicological action
• Common levels and mode of human health related effects. - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- yes
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: rainbow trout
- Strain: Oncorhynchus mykiss
- Source: Donnington fish Farm, Upper Swell, Gloucestershire, UK
- Length at study initiation (length definition, mean, range and SD): 4.5 cm (SD = 0.2)
- Weight at study initiation (mean and range, SD): 1.2 g (SD = 0.26)
- Feeding during test: no the animals were starved from 24 h prior to the study initiation
ACCLIMATION
- Acclimation period: 7 days
- Acclimation conditions (same as test or not): yes
- Type and amount of food: commercial trout pellets
- Health during acclimation (any mortality observed): 2% mortality - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none reported
- Hardness:
- none reported
- Test temperature:
- none reported
- pH:
- range: 7.4-7.9
- Dissolved oxygen:
- none reported
- Salinity:
- Not Applicable
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: non-toxic at the limit of solubility
- Details on results:
- Five acute toxicity tests were conducted with hexadecanol using four different preparation methods. None of the tests resulted in significant mortality due to the action of hexadecanol. Although the deaths in the control (typicaly 10-30%) complicate the interpretation, the data demonstrate that the 96 hour LC50 was greater than the highest concentration tested (10 mg/L). This is about 1000 times the water solubility of hexadecanol.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96 h LC50 >10 mg/L has been determined for the effects of hexadecanol on the mortality of the freshwater fish Brachydanio rerio (new name: Danio rerio). However this result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
- Executive summary:
Five acute toxicity tests were conducted with hexadecanol using four different preparation methods. None of the tests resulted in significant mortality due to the action of hexadecanol. Although the deaths in the control (typicaly 10-30%) complicate the interpretation, the data demonstrate that the 96 hour LC50 was greater than the highest concentration tested (10 mg/L). This is about 1000 times the water solubility of hexadecanol.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Alcohols, C16-18 is a member and is from Long Chain Alcohols (C6-22 primary aliphatic alcohols) category.
The Long Chain Alcohols (C6-22 primary aliphatic alcohols) category is considered suitable as a source of data for Alcohols, C16-18.
Considered valid for read-across for purposes of classification.
No further vertebrate testing can be justified.
Long Chain Alcohols (C6-22 primary aliphatic alcohols) category covers a family of 30 primary aliphatic alcohols within a carbon chain length range of C6-C22. Commercial products generally include several aliphatic alcohol components, with a range of carbon chain lengths present. The family consists of alcohols with varying compositions and structures. Composition depends on the route to manufacture and the related feedstocks. Most of the alcohols have linear carbon chains but certain manufacturing processes create branched structures. Data are also available for eleven other similar substances, which support the category. Non-sponsored alcohols may not be HPV or may not be produced by members of the consortium, but have structures similar to sponsored linear alcohols.
Key points are that the members share:
• The same structural features
• Similar metabolic pathways
• Common mode of ecotoxicological action
• Common levels and mode of human health related effects. - Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- Principles of method if other than guideline:
- The protocol followed in the experiment also took into account the OECD guideline 23 for testing difficult substances and mixtures (2000)
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: An amount of test material (40 mg) was dissolved in tetrahydrofuran with the aid of ultrasonic disruption and the volume adjusted to 10 ml. An aliquot (2.0 ml) of this solution was dispersed in 20L of dechlorinated tap water to give the concentration of 0.4 mg/L.
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): tetrahydrofuran
- Concentration of vehicle in test medium (stock solution and final test solution(s) including control(s)): 2 ml in 20 L, the solvent control group was exposed to 100 ul/L of solvent control. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: rainbow trout
- Strain: Oncorhynchus mykiss
- Source: Donnington fish Farm, Upper Swell, Gloucestershire, UK
- Length at study initiation (length definition, mean, range and SD): 4.5 cm (SD = 0.2)
- Weight at study initiation (mean and range, SD): 1.2 g (SD = 0.26)
- Feeding during test: no the animals were starved from 24 h prior to the study initiation
ACCLIMATION
- Acclimation period: 7 days
- Acclimation conditions (same as test or not): yes
- Type and amount of food: commercial trout pellets
- Health during acclimation (any mortality observed): 2% mortality - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none reported
- Hardness:
- 136 CaCO3 mg/L
- Test temperature:
- 14 degC
- pH:
- range: 7.4-7.9
- Dissolved oxygen:
- greater or equal to 9.3 mg O2/L
- Salinity:
- Not Applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0.4 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): covered
- Material, size, headspace, fill volume: 20 L glass tanks
- Aeration: yes, via narrow bore glass tube
- Renewal rate of test solution (frequency/flow rate): 24 hours
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tap water
- Alkalinity: 80 mg/L
- Conductivity: 405 uS/cm
- Culture medium different from test medium: no
- Intervals of water quality measurement: daily
OTHER TEST CONDITIONS
- Photoperiod: 8 h dark, 16 h light
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : mortality and sub-lethal effects were recorded at 3, 6, 24, 48 and 96 hours.
TEST CONCENTRATIONS
- Justification for using less concentrations than requested by guideline: the test substance was tested up to the limit of solubility.
- Range finding study
- Test concentrations: 0.1 and 1.0 mg/L
- Results used to determine the conditions for the definitive study: 96h EC50 >1.0 mg/L - Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: non-toxic at the limit of solubility
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: non-toxic at the limit of solubility
- Details on results:
- - Mortality of control: 0%
- Effect concentrations exceeding solubility of substance in test medium: the test was conducted above the limit of solubility of the test substance, with the employment of the solvent tetrahydrofuran. The presence of undissolved material was not reported. - Sublethal observations / clinical signs:
No mortalities (0%) were observed in the control, solvent control and 1.0 mg/L groups after 96 h. Therefore the LC50 could not be determined. The water solubility of the test substance is 0.013 mg/l at 25 degC [Yalkowsky et al, 1992]. Therefore the test substance was non-toxic at the limit of solubility.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96 h LC50 >0.4 mg/L has been determined for the effects of hexadecanol on the mortality of the freshwater fish O. mykiss. However this result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.This is about 1000 times the water solubility of the test substance.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fishes species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- Alcohols, C16-18
CAS Number: 67762-27-0
SMILES : CCCCCCCCCCCCCCCCO
CHEM : Alcohols, C16-18
MOL FOR: C16 H34 O1
MOL WT : 242.45
Log Kow: 6.73 (KowWin estimate)
Wat Sol: 0.0412 mg/L (experimental database) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.012 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic at the limit of solubility, as determined by (Q)SAR
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 120 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: Predicted, at water solubility loading rates of 1000 mg/L
- Details on results:
- A 96 h LC50 value of 0.012 mg/L has been calculated for the effects of the test substance on the mortality of the marine fish taxonomic group. This result signifies that the test substance is not expected to be toxic at the limit of solubility.
A reliable 96 h LC50 value of 120 mg/L has been calculated for the effects of the test substance towards fish taxonomic group. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.012 mg/L. Predicted to be non-toxic at the limit of solubility. Predicted to be non-toxic at the limit of solubility.
The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance. - Results with reference substance (positive control):
- A 96 h LC50 value of 0.012 mg/L has been calculated for the effects of the test substance on the mortality of the marine fish taxonomic group. This result signifies that the test substance is not expected to be toxic at the limit of solubility.
- Sublethal observations / clinical signs:
Predicted to be non-toxic at the limit of solubility
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A 96 h LC50 value of 0.012 mg/L has been calculated for the effects of the test substance on the mortality of the marine fish taxonomic group. This result signifies that the test substance is not expected to be toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
A reliable 96 h LC50 value of 120 mg/L has been calculated for the effects of the test substance towards fish taxonomic group. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.012 mg/L. Predicted to be non-toxic at the limit of solubility. Predicted to be non-toxic at the limit of solubility. - Executive summary:
The ECOSAR QSAR model predicts that the 96hr LC50 for maine fish would to be 0.012 mg/l .This result signifies that the test substance is not expected to be toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS. The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
- Qualifier:
- according to guideline
- Guideline:
- other: QSAR
- Principles of method if other than guideline:
- EPI Suite v 4.1/ECOSARv1.00
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fishes species
- Details on test organisms:
- no further information
- Test type:
- other: QSAR model
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- not applicable. QSAR model
- Test temperature:
- not applicable. QSAR model
- pH:
- not applicable. QSAR model
- Dissolved oxygen:
- not applicable. QSAR model
- Salinity:
- not applicable. QSAR model
- Details on test conditions:
- Alcohols, C16-18
CAS Number: 67762-27-0
SMILES : CCCCCCCCCCCCCCCCO
CHEM : Alcohols, C16-18
MOL FOR: C16 H34 O1
MOL WT : 242.45
Log Kow: 6.73 (KowWin estimate)
Wat Sol: 0.0412 mg/L (experimental database) - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.013 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: non-toxic at the limit of solubility, as determined by (Q)SAR
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 130 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: (Q)SAR prediction
- Remarks on result:
- other: Predicted, at an water solubility loading rates of 1000 mg/L
- Details on results:
- A 96 h LC50 value of 0.013 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic at the limit of solubility.
A reliable 96 h LC50 value of 130 mg/L has been calculated for the effects of the test substance towards fish taxonomic group.Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.013 mg/L. Predicted to be non-toxic at the limit of solubility.
The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database).This is about 10000 times the water solubility of the test substance. - Results with reference substance (positive control):
- A 96 h LC50 value of 0.013 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic at the limit of solubility.
- Validity criteria fulfilled:
- yes
- Remarks:
- US EPA accepted QSAR method for chemicals properties assessment.
- Conclusions:
- A 96 h LC50 value of 0.013 mg/L has been calculated for the effects of the test substance on the mortality of the fish taxonomic group. This result signifies that the test substance is not expected to be toxic at the limit of solubility. This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
A reliable 96 h LC50 value of 130 mg/L has been calculated for the effects of the test substance towards fish taxonomic group. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.013 mg/L. Predicted to be non-toxic at the limit of solubility. - Executive summary:
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 0.013 mg/l .This result signifies that the test substance is not expected to be toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS. The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.
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Description of key information
A reliable 96 h LC50 value of 130 mg/L has been calculated for the effects of the test substance towards freshwater fish taxonomic group. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.013 mg/L. Predicted to be non-toxic at the limit of solubility.
This result signifies that the test substance is not expected to be toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS. The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.
A reliable 96 h LC50 value of 120 mg/L has been calculated for the effects of the test substance towards marne fish taxonomic group. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.012 mg/L. Predicted to be non-toxic at the limit of solubility.
This result signifies that the test substance is not expected to be toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS. The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 130 mg/L
Marine water fish
Marine water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 120 mg/L
Additional information
A reliable 96 h LC50 value of 130 mg/L has been calculated for the effects of the test substance towards freshwater fish taxonomic group. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.013 mg/L. Predicted to be non-toxic at the limit of solubility.
This result signifies that the test substance is not expected to be toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS. The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.
A reliable 96 h LC50 value of 120 mg/L has been calculated for the effects of the test substance towards marne fish taxonomic group. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.012 mg/L. Predicted to be non-toxic at the limit of solubility.
This result signifies that the test substance is not expected to be toxic at the limit of solubility.This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS. The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.
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