Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-007-1 | CAS number: 52558-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) is a mono-constituent acid characterized by a water solubility of 0.9 g/L (25 °C, pH 5, EU A.6, flask method), a calculated vapour pressure of 0.174 Pa (25 °C, MPBPWIN v1.43), and a calculated log D of 1.52 at pH 7 and 0.63 at pH 9 (SPARC v4.6). Furthermore, the substance is readily biodegradable (85.2% in 28 d, OECD 301 B, activated sludge) based on a standard biodegradation study with the corresponding salt (Sodium N-methyl-N-(1-oxotetradecyl)aminoacetate, CAS 30364-51-3). The estimated log Koc (Franco, Fu & Trapp model for ionisable substances, 2013) is 2.45 – 4.32 at pH 7, indicating a potential for adsorption to particles present in soil and sediment. Thus, if released into the environment, the substance is expected to distribute into the aquatic and sediment compartments based on the available data. However, it will not persist in these compartments due to ready biodegradability. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in both aquatic and terrestrial environments, including biological sewage treatment plants (ECHA, 2016). Therefore, in accordance with Regulation (EC) No. 1907/2006, Annex IX, Column 2, 9.2.1.2 – 9.2.1.4, further simulation testing for biodegradation in water and sediment or soil is not required. Abiotic degradation via hydrolysis or phototransformation in air is not a relevant environmental fate pathway based on the ready biodegradability and low vapour pressure of the substance, respectively.
N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3) has calculated log D (considered for ionisable substances instead of log Kow) of 1.52 at pH 7 and 0.63 at pH 9 (SPARC v4.6), indicating low lipophilicity at environmentally relevant pH ranges of 7 and above. According to REACh regulation (EC) No 1907/2006 a substance has a low potential for bioaccumulation when the log D is ≤ 3.0. Furthermore, the predicted BCF values provide evidence that the potential for bioaccumulation in aquatic organisms is likely low. The calculated BCF values range from 10 – 306.9 L/kg wet-wt (BCFBAF v3.01) and are thus well below the threshold value of 2000 L/kg for bioaccumulative substances, as laid down by the REACH regulation (EC) No 1907/2006, section 1 of Annex XIII.
Moreover, the substance is readily biodegradable and will therefore not persist in the environment. Hence, its bioavailability to aquatic organisms is expected to be low due to low discharge into the environment (owing to extensive biodegradation in conventional STPs as a result of adsorption properties) on the one hand and minimal persistence due to ready biodegradability on the other hand. In addition, toxicokinetic considerations with regard to absorption, distribution, metabolisation and excretion of the substance provide further evidence for a low bioaccumulation potential. While absorption after oral uptake is considered likely, systemic distribution, accumulation and metabolisation of the substance is not anticipated and urinary excretion is expected to be an important and rapid excretion pathway based on experimental mammalian studies with structurally similar substances (for further details, please refer to the toxicokinetic statement in IUCLID section 7.1). In conclusion, the potential for bioaccumulation is expected to be low for N-(1-oxotetradecyl)sarcosine (CAS 52558-73-3).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.