Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-730-4 | CAS number: 42233-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
BMFK (kinetic dietary BMF): 0.0058
BMFKg (growth-corrected kinetic dietary BMF): 0.0088
BMFKgL (lipid-corrected growth-corrected kinetic dietary BMF): 0.0427
Key value for chemical safety assessment
Additional information
The bioaccumulation and depuration of the test substance in rainbow trout was investigated by means of a fish feeding study in a dynamic flow through system (Burri, 2014). Biomagnification factors (BMF) in fish were determined. The fish were fed during 14 days in a flow-through system with food containing a target concentration of 1000 µg/g radiolabelled test item. After the exposure, the fish were transferred to flowing untreated water and the depuration of radioactivity was followed for further 28 days.
Temperature, pH and oxygen concentration during the whole study were within acceptable limits; measurements ranged from 13.3-14.2 °C, 7.8-8.2 and 8.4-9.5 mg/L, respectively. By determination of the radioactivity level, the content of the test item in the food was confirmed.
A level of 1053.5 µg/ g food was measured immediately after preparation. A level of 1038.3 µg/ g food was measured after 18 days of storage at -20 °C. At the end of the feeding period, the test item concentration in fish amounted to 8.523 ± 4.803 µg/ g fish. At day 1 of depuration, the concentration in the fish had decreased to 3.419 µg/ g fish. The level on day 7 was 1.622 µg/ g fish. At the end of the depuration phase (day 42), the radioactivity concentration was 1.249 µg/ g fish. An additional measurement was performed after 3 days of uptake. The mean value of 5 fish amounted to 14.487 ± 6.866 µg/ g fish.
Fish growth rates for the control fish and the test fish were similar. The growth rate of the test fish was 0.017 day-1. The rate constant k2 for the depuration of the radioactivity from the fish was calculated to be 0.051 day-1. Therefore, the growth-corrected rate constant k2g was 0.034 day-1. The growth corrected half-life was therefore 20.5 days.
The derived time 0 concentration C0,d was 3.122 µg/g and the content of test item in the diet was 1053.5 ng/g. Based on these values and a feeding rate of 0.02 g food/g fish/day, the substance assimilation efficiency alpha was calculated to be 0.0148.
Kinetic BMFK, growth-corrected BMFKg and lipid-corrected growth-corrected BMFKgL amounted to 0.0058, 0.0088 and 0.0427, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.