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EC number: 255-673-5 | CAS number: 42131-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22nd November 2017 to 18th January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Isotridecyl isononanoate
- EC Number:
- 255-673-5
- EC Name:
- Isotridecyl isononanoate
- Cas Number:
- 42131-27-1
- Molecular formula:
- C22H44O2
- IUPAC Name:
- Isotridecyl isononanoate
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment: freshwater
- Details on inoculum:
- Surface water was collected from Malmesbury Pond, Sandymoor, Runcorn on13th November 2017 and assigned a batch number of SE17003. It was filtered to remove coarse particles and aerated at 22 ± 2ºC prior to use. The surface water was then added to test media so as to achieve a final concentration of 100ml per litre of test media. The test suspensions were then aerated until the study pre-conditioning period was ready to commence on 17th November 2017
- Duration of test (contact time):
- 56 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 12.9 mg/L
- Based on:
- test mat.
- Initial conc.:
- 25.7 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- 3.1 Test medium: Test medium was prepared according to the method detailed in Cheshire Eco Solutions SOP III.19.
3.2 Test vessels: Conical flasks containing 3000 ml of test media.
3.3 Inoculum: Surface water was collected from Malmesbury Pond, Sandymoor, Runcorn on 13th November 2017 and assigned a batch number of SE17003. It was filtered to remove coarse particles and aerated at 22 ± 2ºC prior to use. The surface water was then added to test media so as to achieve a final concentration of 100ml per litre of test media. The test suspensions were then aerated until the study pre-conditioning period was ready to commence on 17th November 2017.
3.4 Test material: Test material was added directly to the test vessels after being accurately weighed ontoglass cover slips to give a final test
concentrations of 12.9 mg/l and 25.7 mg/l. A control vessel was run in parallel, this contained inoculum but no test or reference material. A test vessel containing 102.9 mg (20 mg C/l) of the reference material, sodium benzoate (Batch No: 304526) in 3 litres of test media, was also included in the test. In addition a vessel containing 102.9 mg (20 mg C/l) of the reference material, sodium benzoate and test material at 25.7 mg/l in 3 litres of test media, was also included as an inhibition control.
3.5 Test conditions: 3 Litre volumes of test media were stirred constantly in round, flat bottomed flasks in the dark. Carbon dioxide free air was passed through the test solutions at an estimated rate of 30 to 100ml per minute. This was in turn passed through two dreschel bottles, per test vessel, containing barium hydroxide of known concentration and volume. The tests were carried out in the laboratory at 22 ± 2°C. Single vessels were prepared for each test material concentration.
Results and discussion
% Degradationopen allclose all
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 95.8
- Sampling time:
- 56 d
- Remarks on result:
- other: Starting concentration
- Remarks:
- 12.9 mg/l
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 44.8
- Sampling time:
- 56 d
- Remarks on result:
- other: Starting concentration
- Remarks:
- 25.7 mg/l
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 76.4
- Sampling time:
- 28 d
- Remarks on result:
- other: Starting concentration
- Remarks:
- 12.9 mg/l
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 33
- Sampling time:
- 28 d
- Remarks on result:
- other: Starting concentration
- Remarks:
- 25.7 mg/l
- Details on results:
- A figure of 60% degradation within 28 days is usually taken as being indicative of a good potential for degradation. According to this guideline, under these test conditions in the OECD 301B Procedure, Isotridecyl isononanoate showed good potential for degradation at the test concentration of 12.9 mg/l and limited potential at 25.7 mg/l after 28 days in this study.
After 56 days Isotridecyl isononanoate also showed good potential for degradation at the test concentration of 12.9 mg/l and limited potential at 25.7 mg/l. The final 56-day cumulative % degradation values were determined to be 95.8% at 12.9 mg/l and 44.8% at 25.7 mg/l.
Any other information on results incl. tables
Cumulative degradation | ||||
Day of Titration | Sodium Benzoate (34.3 mg/l) | Isotridecyl isononanoate (12.9 mg/l) | Isotridecyl isononanoate (25.7 mg/l) | Inhibition Control** |
1 | 22.4 | * | 2.5 | * |
3 | 44.0 | 4.3 | 5.3 | 15.5 |
5 | 50.1 | 17.2 | 5.6 | 36.1 |
8 | 54.9 | 27.8 | 9.8 | 46.1 |
10 | 58.0 | 27.6 | 11.7 | 53.0 |
14 | 63.8 | 44.4 | 17.0 | 65.5 |
19 | 66.7 | 55.9 | 26.0 | 74.4 |
23 | 68.9 | 65.8 | 29.0 | 81.7 |
28 | 71.1 | 76.4 | 33.0 | 86.8 |
35 | 70.2 | 75.8 | 34.9 | 97.0 |
42 | 76.4 | 78.3 | 39.3 | 100.5 |
49 | 79.8 | 85.4 | 41.1 | 110.5 |
56 | 83.4 | 89.2 | 43.4 | 114.2 |
57 | 87.2 | 95.8 | 44.8 | 118.3 |
* Indicates negative degradation | ||||
** inhibition Control contained sodium benzoate at 34.3 mg/L and test material at 25.7 mg/l in 3 litres of test media. |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- From the results of this study it can be concluded that Isotridecyl isononanoate does not meet the criteria for classification as 'readily biodegradable' according to the OECD 301B method of >60.0% biodegradation being achieved within the 10-day window. However it did prove to be ‘ultimately biodegradable’ with >60.0% biodegradation being achieved within the initial 28-day test period.
- Executive summary:
While the study correctly concludes that the substance is not readily biodegradable, the criteria given in CLP on Rapid degradability of organic substances states in section 4.1.2.9.5(c) that if there is convincing evidence that >70% degradation is achieved within a 28 day period then a substance may also be considered rapidly biodegradable.
As applies to Isotridecyl isononanoate and the results obtained in this study at the 12.9 mg/L concentration (the lower threshold defined by the guideline of 10mg TOC/l), the substance can be considered rapidly biodegradable for the purposes of classification in accordance with CLP.
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