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EC number: 241-047-9 | CAS number: 16970-55-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an OECD Test Guideline 423 study, to GLP, the acute oral LD50 value of dihydrogen tetrachloropalladate (solution) was determined to range between 200 and 2000 mg/kg bw following gavage administration in rats (van Huygevoort, 2003a).
No relevant acute dermal or inhalation toxicity data were identified. However, acute toxicity testing by a second route is not considered appropriate as dihydrogen tetrachloropalladate is considered corrosive to the skin.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 November 2002 to 18 December 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD, EU), to GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- 200 mg/kg bw dose instead of the recommended 300 mg/kg bw
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- 200 mg/kg bw dose instead of the recommended 300 mg/kg bw
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- other: Wistar strain Crl(WI) BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland
Sulzfeld
Germany
- Age at study initiation: about 8 weeks
- Weight at study initiation: males 254-269 g
females 157-183 g
- Fasting period before study: overnight
- Housing: Macrolon cages, on sawdust
- Diet (e.g. ad libitum): conventional diet, ad libitum
- Water (e.g. ad libitum): tap water; ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 3
- Humidity (%): 30-70
- Air changes (per hr): about 15
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
No vehicle. Test substance (in solution) was dosed undiluted as delivered by the sponsor.
MAXIMUM DOSE VOLUME APPLIED: 0.13 and 1.33 ml/kg bw (for 200 and 200 mg/kg bw dose, respectively) - Doses:
- 200 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 200 mg/kg bw 3/sex
2000 mg/kg bw 3 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: continuous on day of dosing, then daily
- Necropsy of survivors performed: yes - Statistics:
- none
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Remarks on result:
- other: CL not determined
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Remarks on result:
- other: CL not determined
- Mortality:
- 2000 mg/kg bw all three females were sacrificed due to distress on day 1 after dosing.
200 mg/kg bw one male died on day 2; all 3 females survived. - Clinical signs:
- other: 2000 mg/kg bw lethargy, hunched posture, uncoordinated movements, piloerection, quick breathing (lasting 1 hr), slow breathing (on day 1). In addition, individual animals exhibited ptosis and vomiting with red spots, hypothermia, rales and laboured breath
- Gross pathology:
- 2000 mg/kg bw the glandular mucosa of the stomach was hardened and had a black discolouration. One female also showed a yellowish discolouration of the liver and a reddish, clear fluid in the abdominal cavity.
200 mg/kg bw no abnormal findings in animals that survived the observation period. The deceased male had a thickened glandular mucosa, gastro-intestinal tract distended with gas and dilation of the right kidney. - Other findings:
- - Organ weights: not examined
- Histopathology: not examined
- Potential target organs: no data - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In a GLP OECD Test Guideline 423 study, to GLP, the acute oral LD50 value of dihydrogen tetrachloropalladate (solution) was determined to range between 200 and 2000 mg/kg bw [expressed as compound dose] following gavage administration in rats.
- Executive summary:
In a OECD Test Guideline 423 study, to GLP, dihydrogen tetrachloropalladate (solution) was studied for acute oral toxicity after single gavage administration in Wistar rats. The test substance was administered undiluted as a brown liquid at a dose [expressed as compound dose] of 200 mg/kg bw to both sexes (3/sex/dose) and at 2000 mg/kg bw to 3 females.
All females dosed at 2000 mg/kg bw were sacrificed due to distress on day 2 after dosing. Clinical signs showed lethargy, hunched posture, uncoordinated movements, piloerection, quick breathing (lasting 1 hr after dosing), slow breathing (on day 1). In addition, individual animals exhibited ptosis, vomiting with red spots, hypothermia, rales and laboured breathing. At 200 mg/kg bw all animals had hunched posture and rales; piloerection was observed in the females and one female also showed chromodacryorrhoea around the snout. Symptoms lasted between 1 and 7 days in females and 2 days in males. Necropsy of the females dosed at 2000 mg/kg bw showed hardening of the glandular mucosa of the stomach and a black discolouration. One female also exhibited a yellowish discolouration of the liver and a reddish, clear fluid in the abdominal cavity. No abnormal findings were evident in the animals dosed at 200 mg/kg bw and which survived the observation period. The deceased male at necropsy exhibited a thickened glandular mucosa, gastro-intestinal tract distended with gas and dilation of the right kidney.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 300 mg/kg bw
- Quality of whole database:
- Overall, good-quality database which meets REACH Standard Information Requirements.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant acute toxicity human data were identified.
In an OECD Test Guideline 423 study, to GLP, dihydrogen tetrachloropalladate (solution) was studied for acute oral toxicity after single gavage administration in Wistar rats. The test substance was administered undiluted as a brown liquid at a dose of 200 mg/kg bw to both sexes (3/sex) and at 2000 mg/kg bw to 3 females. All females dosed at 2000 mg/kg bw were sacrificed due to distress on day 2 after dosing. Clinical signs included lethargy, hunched posture, uncoordinated movements, piloerection, quick breathing (lasting 1 hr after dosing) and slow breathing (on day 1). In addition, individual animals exhibited ptosis, vomiting with red spots, hypothermia, rales and laboured breathing. At 200 mg/kg bw all animals had hunched posture and rales; piloerection was observed in the females and one female also showed chromodacryorrhoea around the snout. Symptoms lasted between 1 and 7 days in females and 2 days in males. Necropsy of the females dosed at 2000 mg/kg bw showed hardening of the glandular mucosa of the stomach and a black discolouration. One female also exhibited a yellowish discolouration of the liver and a reddish, clear fluid in the abdominal cavity. No abnormal findings were evident in the animals dosed at 200 mg/kg bw that survived the observation period. The deceased male at necropsy exhibited a thickened glandular mucosa, gastro-intestinal tract distended with gas and dilation of the right kidney. Under the conditions of this test, an acute oral LD50 value for dihydrogen tetrachloropalladate solution was determined to be in the range between 200 and 2000 mg/kg bw following gavage administration in rats (van Huygevoort, 2003a). This is considered to approximate to a discriminating dose of 300 mg/kg bw. Based on the results of this acute oral rat study, dihydrogen tetrachloropalladate (solution) is classified for acute oral toxicity (category 4) according to EU CLP criteria (EC 1272/2008).
No relevant acute dermal or inhalation toxicity data were identified. However, acute toxicity testing by a second route is not considered appropriate as dihydrogen tetrachloropalladate (solution) is corrosive to the skin.
Justification for selection of acute toxicity – oral endpoint
OECD guideline study, to GLP, and the only acute oral toxicity study available
Justification for classification or non-classification
Based on the results of the available acute oral rat study, dihydrogen tetrachloropalladate (solution) is classified for acute oral toxicity (category 4) according to EU CLP criteria (EC 1272/2008).
No clear evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
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