Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-439-8 | CAS number: 7550-35-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the QMRF and QPRF files provided under the section attached justification.
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSAR R.6
- Deviations:
- no
- Principles of method if other than guideline:
- KOCWIN (v2.00): estimation using first-order Molecular Connectivity Index (MCI)
- GLP compliance:
- no
- Type of method:
- other: Calculation
- Specific details on test material used for the study:
- SMILES: [Li]Br
- Test temperature:
- 25 °C
- Key result
- Type:
- log Koc
- Value:
- 1.121 dimensionless
- Temp.:
- 25 °C
- Remarks on result:
- other: The substance is not within the applicability domain of the model.
- Conclusions:
- Using KOCWIN v2.00 the log KOC of the test item was calculated to be 1.121 (Koc = 13.22 L/kg) at 25 °C. The substance is not within the applicability domain of the model. Thus the estimation may be less accurate.
- Executive summary:
The log Koc was calculated using KOCWIN v2.00 as part of EPISuite v4.11 from US Environmental Protection Agency.
Using KOCWIN v2.00 the log KoC of the test item was calculated to be 1.121 at 25 °C (EPI Suite, 2014).
The adequacy of a prediction depends on the following conditions:
a) the (Q)SAR model is scientifically valid: the scientific validity is established according to the OECD principles for (Q)SAR validation;
b) the (Q)SAR model is applicable to the query chemical: a (Q)SAR is applicable if the query chemical falls within the defined applicability domain of the model;
c) the (Q)SAR result is reliable: a valid (Q)SAR that is applied to a chemical falling within its applicability domain provides a reliable result;
d) the (Q)SAR model is relevant for the regulatory purpose.
For assessment and justification of these 4 requirements the QMRF and QPRF files were developed and attached to this study record.
Description of the prediction Model
The prediction model was descripted using the harmonised template for summarising and reporting key information on (Q)SAR models. For more details please refer to the attached QSAR Model Reporting Format (QMRF) file.
Assessment of estimation domain
The assessment of the estimation domain was documented in the QSAR Prediction Reporting Format file (QPRF). Please refer to the attached document for the details of the prediction and the assessment of the estimation domain.
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- other justification
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter
- Justification for type of information:
- In accordance to column 2 of REACH Regulation (EC) No 1907/2006, Annex VIII, section 9.3.1, the adsorption/desorption screening test does not need to be conducted as due to its physico-chemical properties a low adsorption potential for lithium bromide is expected. The theoretical, calculated log Pow is very low, as expected for an inorganic salt.
- Reason / purpose for cross-reference:
- data waiving: supporting information
Referenceopen allclose all
KOCWIN Program (v2.00) Results:
==============================
SMILES : [Li]Br
CHEM : Lithium bromide
MOL FOR: Br1 Li1
MOL WT : 86.84
--------------------------- KOCWIN v2.00 Results --------------------------
NOTE: METAL (Na, Li or K) HAS BEEN REMOVED TO ALLOW ESTIMATION via MCI!
WARNING - The entered structure is an INORGANIC Compound. Inorganic compounds were not included in the training data set for the methodology utilized in this program. Therefore, inorganic compounds are outside the estimation domain.
Koc Estimate from MCI:
First Order Molecular Connectivity Index |
1.000 |
Non-Corrected Log Koc (0.5213 MCI + 0.60) |
1.1211 |
Fragment Correction(s) |
None |
Corrected Log Koc |
1.1211 |
Description of key information
In accordance to column 2 of REACH Regulation (EC) No 1907/2006, Annex VIII, section 9.3.1, the adsorption/desorption screening test does not need to be conducted as due to its physico-chemical properties a low adsorption potential for lithium bromide is expected. The theoretical, calculated log Pow is very low, as expected for an inorganic salt.
Key value for chemical safety assessment
- Koc at 20 °C:
- 13.22
Additional information
Lithium bromide quickly dissociates in water forming the lithium and bromide ion. The calculation of adsorption of lithium bromide with EPI Suite v4.11 can be seen as estimation as only a few inorganic compounds were included in the training data set of the program. But taken into account the quick dissociation of lithium bromide in water this EPI Suite estimation can be regarded as adequate enough to be used for the risk assessment.
The absorption affinity of lithium bromide was estimated using KOCWIN v2.00 embedded in EPI Suite v4.11 of EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC). The program is a screening level tool and estimates the soil sorption coefficient log Koc of chemicals using a molecular topology/fragment contribution method. Lithium bromide has a molecular weight of 86.85 g/mol and therefore does fit the applicability domain of this model. A log Koc of 1.121 (Koc = 13.22 L/kg) was derived for lithium bromide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.