6-hydroxy-1H-pyrimidin-4-one

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16-Jun-2010 to 01-Jul-2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study conducted in compliance with OECD and EU Guidelines.

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling point/boiling range)

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Atm. press.:

99 kPa

Decomposition:

yes

Decomp. temp.:

210 °C

Remarks on result:

other: The test item decomposes starting at about 210 °C before boiling occurs

Preliminary Test

 

The DSC-curve of the preliminary test (heating rate of 20 °C/min from 25 °C to 400 °C) is shown in the report. An endothermic heat effect was observed at about 225.4 °C. An exothermic heat effect was detected at about 257.6 °C. After the experiment, the sample had lost 28.5% of its mass and a black powder remained in the sample cup.

 

Main Test               

A further DSC run was recorded between 25 °C and 400 °C with a heating rate of 10 °C/min. Decomposition of the test item started at about 210 °C before boiling occurred.

Conclusions:

The study is considered to be reliable without restrictions.

Description of key information

The substance decomposes starting at about 210 °C before boiling occurs (the atmospheric pressure during the boiling point measurements was 99.0 kPa), EU Method A.2, DSC, Weissenfeld, 2010

Additional information

The study on Boiling Point was not performed under GLP, however it has been conducted in compliance with OECD and EU Guidelines. The result is considered to be reliable and adequate for classification, labeling and risk assessment purposes.