Methanesulfonamide, 1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2000

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Simplified study not GLP, following standardised guidelines.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2000

Report date:

2000

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Deviations:

yes

Remarks:

only one animal was used

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

435-300-4

EC Name:

-

Cas Number:

82113-65-3

Molecular formula:

C2HNO4F6S2

IUPAC Name:

1,1,1-trifluoro-N-trifluoromethanesulfonylmethanesulfonamide

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

TEST ANIMALS
- Source: Charles River Italia S.p.A.
- Weight at study initiation: 3.2 kg
No more information available.

Test system

Vehicle:

unchanged (no vehicle)

Controls:

other: the other eye served as reference.

Amount / concentration applied:

100 mg

Duration of treatment / exposure:

1 hour

Number of animals or in vitro replicates:

1

Details on study design:

A 100 mg aliquot of the test substance was introduced into the right eye of a single animal by gently pulling away the lower lid from the eyeball to form a cup into which the test substance was placed. The lids were then held shut for a few seconds to prevent loss of the test substance. The left eye remained untreted.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: 1 hour

SCORING SYSTEM: Draize

Results and discussion

In vivo

Results

Irritation parameter:

cornea opacity score

Basis:

animal #1

Time point:

other: 1 hour

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: the animal was humanely killed

Other effects:

Response assessed immediately after dosing. Immediately after dosing extreme corneal opacity was apparent and the animal was humanely killed.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye)

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

TFSIH causes severe eye damage.

Executive summary:

In a study (2000), bis trifluoromethanesulfonamide was introced in the eye of one rabbit.

Immediately after dosing extreme corneal opacity was apparent and the animal was humanely killed.

In these conditions test item causes irreversible eye damage and classified eye damage category 1 (H318), according to the CLP 1272/2008.