Registration Dossier
Registration Dossier
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EC number: 608-211-5 | CAS number: 284462-37-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6/2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 0.9
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: mean value from 3 single values
- Conclusions:
- The partition coefficient (log pow) of the substance was 0.9 at 25 °C and pH 7.1.
- Executive summary:
The partition coefficient was determined by using EU method A. 8 (HPLC method). The average log Pow of 0.9 was determined from 3 single values. In order to ensure a stable performance of the HPLC column, the column temperature was set to 40°C. However, the temperature of the log Pow of the test substance is dependent on the one of reference substance; and hence the determined log Pow is at 25°C.
Reference
Description of key information
The partition coefficient (log pow) of the substance was 0.9 at 25 °C and pH7.1
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.9
- at the temperature of:
- 25 °C
Additional information
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