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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
425-220-8
EC Name:
-
Cas Number:
5945-33-5
Molecular formula:
C39H34O8P2
IUPAC Name:
(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: limited test
Mortality:
no death
Clinical signs:
No signs of systemic toxicty were observed during the observation period.


Body weight:
All animals showed expected gain in bodyweight
Gross pathology:
No signs of skin irritation were noted during the study. No abnormalities were noted at necropsy.

Other findings:
Nothing to add in this field.

Any other information on results incl. tables

Mortality: No deaths were recorded.

Clinical observations: No clinical signs of toxicity were noted.

Morphological findings: No signs of skin irritation were noted during the study. No abnormalities were noted at necropsy.

Comment: All animals showed expected gain in bodyweight.

LD50: > 2 000 mg/kg

Result: The test chemical was of low dermal toxicity in rats.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The test material has low toxicity via acute dermal toxicity study in rats.
Executive summary:

According to OECD TG 402, the acute dermal toxicity test was well conducted and the results indicated the test material has very low toxicity in rats.