Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-chloro-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

2014

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study is classified as reliable with restrictions because it is an acceptable and reliable study carried out by OECD ToolBox 3.2.0. Meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference

Reference Type:

other: software

Title:

QSAR ToolBox 3.2.0.103

Author:

OECD

Year:

2014

Bibliographic source:

http://www.oecd.org/env/ehs/risk-assessment/theoecdqsartoolbox.htm

Materials and methods

Principles of method if other than guideline:

Read-across from category members

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

17-hydroxypregna-4,9(11)-diene-3,20-dione

EC Number:

251-868-4

EC Name:

17-hydroxypregna-4,9(11)-diene-3,20-dione

Cas Number:

34184-82-2

IUPAC Name:

17-hydroxypregna-4,9(11)-diene-3,20-dione

Constituent 2

Reference substance name:

Androst-4-ene-3,17-dione

EC Number:

200-554-5

EC Name:

Androst-4-ene-3,17-dione

Cas Number:

63-05-8

IUPAC Name:

androst-4-ene-3,17-dione

Constituent 3

Reference substance name:

2668-75-9

EC Number:

607-988-8

Cas Number:

2668-75-9

IUPAC Name:

2668-75-9

Constituent 4

Reference substance name:

17β-hydroxy-17-(3-hydroxypropyl)androst-4-ene-4-one

EC Number:

259-701-7

EC Name:

17β-hydroxy-17-(3-hydroxypropyl)androst-4-ene-4-one

Cas Number:

55542-27-3

IUPAC Name:

55542-27-3

Constituent 5

Reference substance name:

103335-54-2

EC Number:

600-423-6

Cas Number:

103335-54-2

IUPAC Name:

103335-54-2

Test animals

Species:

rat

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2 110 mg/kg bw

Any other information on results incl. tables

Toxicity of the target chemical (2.11E+03 mg/kg) is predicted from category members using read-across based on 5 values within the range 2891 - 2.00E+03 mg/kg from 5 nearest neighbours compared by prediction descriptors. Category members are single chemicals or mixtures and are selected based on the profile of the target chemical. Only chemicals having experimental data are listed in the category.

The target chemical FALLS within applicability domain of the prediction.

The descriptor values for the target chemical and the category members in case they are set of tautomers, set of metabolites or mixtures are calculated using the following rule(s):

1. "logP Multicase" - taking the weighted average value

2. "Number of rings" - taking the weighted average value

3. "Similarity" - taking the weighted average value

The endpoint data used in the prediction is selected from the following database(s):

1. ECHA CHEM

The prediction is based on 5 values within the range 2.20 - 2.51, log(1/mol/kg)

Prediction confidence = ± 0.157, log(1/mol/kg) (95.0%)

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Not acute toxicant by oral route.