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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals.

Data source

Reference
Reference Type:
publication
Title:
TOXICITY STUDIES of ETHYLBENZENE (CAS No. 100-41-4) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES).
Author:
NTP
Year:
1992
Bibliographic source:
NATIONAL TOXICOLOGY PROGRAM March 1992 NTP TOX 10 NIH Publication No. 92-3129 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service, National Institutes of Health.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 471 (Bacterial Reverse Mutation Assay)
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene

Method

Target gene:
Salmonella typhimurium

Strains: TA100, TA1535, TA97,TA98
Test concentrations with justification for top dose:
Doses: up to 1000 μg/plate

Results and discussion

Any other information on results incl. tables

Study observed:

 

Negative in the presence and absence of exogenous metabolic activation (S9) when tested at doses up to 1000 μg/plate.

Applicant's summary and conclusion

Conclusions:
Ethylbenzene was not genotoxic in Mutagenicity study in Salmonella typhimurium in the presence and absence of exogenous metabolic activation (S9) when tested at doses up to 1000 μg/plate.