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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals.

Data source

Reference
Reference Type:
review article or handbook
Title:
Sax's Dangerous Properties of Industrial Materials.
Author:
Lewis, R.J.
Year:
1996
Bibliographic source:
9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Handbook data
Principles of method if other than guideline:
Handbook data: Rats, oral Acute toxicity
GLP compliance:
not specified
Test type:
other: Handbook data

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
ethylbenzene

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Any other information on results incl. tables

LD50 (Rat, oral) = 3500 mg/kg.

Applicant's summary and conclusion

Conclusions:
In accordance with the CLP Regulation criteria, a substance is classified as to its acute oral toxicity if LD50 ≤2 000 mg/kg bw. The published data on acute oral toxicity of ethylbenzene is above the cut off value of 2000 mg/kg bw for classification.

It is, therefore, considered that ethylbenzene is of low acute toxicity in experimental animals by oral exposure route.