(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The information of this endpoint has been provided by ECHA as a result of an inquiry, thus the full access to data in the report is not accessible to the registrant. However the reliability is estimated to be at level 1: Study conducted in accordance with generally accepted scientific principles. Possible deficiencies do not affect the quality of relevant results.

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 92/69/EEC, C2

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

413-110-2

EC Name:

-

Cas Number:

135861-56-2

Molecular formula:

C24H30O6

IUPAC Name:

1-[2,6-bis(3,4-dimethylphenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Details on test solutions:

Identity and concentration of auxiliary solvent for dispersal: dimethylformamide

Test organisms

Test organisms (species):

other: aquatic crustacea: DM

Test conditions

Hardness:

CA 270 mg CaCO3/L

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

> 0.1 mg/L

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 0.1 mg/L

Effect concentrations 3

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

> 0.1 mg/L

Effect concentrations 4

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

>= 0.1 mg/L

Details on results:

%Concentration loss over test: 0 ...

Applicant's summary and conclusion

Validity criteria fulfilled:

not specified

Conclusions:

Test details are not available. The 24 and 48 h EC50 values and 48 h EC 100 values of the test substance on Daphnia magna were > 0.1 mg/L nominal, the highest attainable test consentration using dimethylformamide as an auxiliary solvent. The test method was an EU C.2 limit test under GLP.
The 48 h NOEC >= 0.1 mg/L nominal.

Executive summary:

The 48 h EC₅₀value of the test substance on Daphnia magna was > 0.1 mg/L nominal, the highest attainable test consentration using dimethylformamide as an auxiliary solvent. The test method was an EU C.2 limit test under GLP.

The 48 h NOEC >= 0.1 mg/L nominal, the solubility limit of the substance, indicating no acute toxicity at levels up to water solubility.

Concentrations were confirmed analytically.

As the study was conducted under GLP and the study was already assessed by authorities, it was considered valid, and selected as key.