Registration Dossier
Registration Dossier
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EC number: 204-552-5 | CAS number: 122-52-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (publicly available peer reviewed source). Original document not available.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- UNEP Publications
- Reference Type:
- publication
- Title:
- Acute evaluation of triethyl phosphite.
- Author:
- Kinkead ER, Wolfe RE, Bunger SK, Pollard DL
- Year:
- 1 992
- Bibliographic source:
- Acute Toxic. Data 1, 217-218. Cited in SIDS Initial Assessment Report For SIAM 16 (Triethyl Phosphite), 2003 Paris.
Materials and methods
- Principles of method if other than guideline:
- Compound was applied to 5 rabbits per sex and dose to an area of approx. 30% total body surface at 2.0, 2.5 and 3.0 g/kg bw and was covered with gauze bandage, plastic wrap, and elastic tape. After 24 h the covers were removed, wiped clean, and observed for 14 days.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Triethylphosphite
- IUPAC Name:
- Triethylphosphite
- Details on test material:
- Purity: no data.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Weight: 2-3 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Compound was applied to an area approx. 30% total body surface and was covered with gauze bandage, plastic wrap, and elastic tape.After 24 h the covers were removed, wiped clean, and observed for 14 days.
- Duration of exposure:
- 24 h
- Doses:
- 2.0, 2.5 and 3.0 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no data
- Other examinations performed: no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 800 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No data.
- Clinical signs:
- No data.
- Body weight:
- No data.
- Gross pathology:
- No data.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
