Registration Dossier
Registration Dossier
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EC number: 204-070-5 | CAS number: 115-19-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
An embryotoxicity/teratogenicity study was carried out according to EU method B.31 and OECD guideline 414. Groups of 25 female Wistar rats were administered doses of 0 (controls), 45, 130 and 400 mg/kg bw/day for day 6 through day 15 post coitum. Maternal toxicity was seen in the highest dose group in the form of body weight loss associated with reduced feed consumption, as well as apathy, reeling and piloerection, which were reversible at the end of treatment. The fetuses of this dose group showed reduced fetal weights, skeletal variations and retardations, but no detectable teratogenic effects. The no observed adverse effect level for the mothers and the fetuses was found to be 130 mg/kg bw/day.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 130 mg/kg bw/day
Justification for classification or non-classification
Based on the data available the substance is not classified or labeled according to Directive 67/548/EEC (DSD) or Regulation 1272/2008/EC (CLP).
Additional information
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