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EC number: 401-540-3
CAS number: 84632-65-5
The animals were killed 168 h p.a.. During the 168 h 0.3 resp. 0.6% of
the applied redioactivity was found in the urine. These small amounts
are interpreted as technic-related faecalic impurities.
The pare which was incorporated in the faeces were in average 119.7%
(low dose group) rsp. 96.0%. The corresponding fraction after 24h was
101.4% rsp. 79.7%. In both dosage groups only neglictible amounts of the
radioactive substance were detected in the organs and the tissue, in the
intestinal tract, in the blood and in the carcasse. The maximal
concentration in the blood was 0.139 ag/g (low dosage group) rsp. 1.152
ag/g and in the plasma 0.140 rsp. 1.048 ag/g. The maxima were reached 1
to 2 h after application. As the concentration is close to the detection
limit the kinetics of the elimination and the area under the curve could
not be calculated.
From the study can be stated that the notified substance is not
bioavailable when it is applied once orally under the conditions
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