Registration Dossier
Registration Dossier
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EC number: 916-533-5 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96 hour LC50 84.4 mg/L (95 % confidence limits 52.27 - 162.50), 96 hour NOEC 56.7 mg/L, 96 hour LOEC 128.5 mg/L, OECD 203, EU Method C.1, EPA OPPTS 850.1075, Japanese MAFF (2-7-1), Sipos (2013c).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 84.4 mg/L
Additional information
In the key study (Sipos, 2013c), the acute toxicity of the test material to fish was determined in an acute toxicity study using Cyprinus carpio. The study was performed under GLP conditions and in line with the standardised guidelines OECD 203, EU Method C.1, EPA OPPTS 850.1075, and Japanese MAFF (2-7-1).
Based on the results of the preliminary range-finding test 7 fish per concentration were exposed for 96 hours under semi-static conditions at nominal test material concentrations of 19.1, 34.3, 61.7, 111.1 and 200 mg/L. Corresponding to measure geometric mean concentration of 7.7, 34.4, 56.7, 128.5 and 239.4 mg/L. Since measured values deviated more than 20 % of the nominal, effect parameters were expressed in terms of measured concentrations.
Under the conditions of the test, mortality was observed at measured concentrations of ≥ 128.5 mg/L. No sub-lethal effects were observed during exposure. Based on these results it was possible to calculate the following effect parameters; LC50 84.4 mg/L (95 % confidence limits 52.27 - 162.50 mg/L); NOEC 56.7 mg/L; LOEC 128.5 mg/L.
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