Registration Dossier
Registration Dossier
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EC number: 200-076-7 | CAS number: 51-03-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- The Absorption, Distribution, Metabolism and Excretion of Piperonyl Butoxide in Mammals
- Author:
- Cockburn, A., Needham, D.
- Year:
- 1 998
- Bibliographic source:
- Jones, D.G. Piperonyl butoxide The Insecticide Synergist, Academic press, San Diego, p 137-152
- Reference Type:
- review article or handbook
- Title:
- Piperonyl Butoxide
- Author:
- Moretto, A.
- Year:
- 1 995
- Bibliographic source:
- WHO JMPR
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Piperonyl Butoxide
- IUPAC Name:
- Piperonyl Butoxide
- Details on test material:
- no data
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- other: CD
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Duration and frequency of treatment / exposure:
- Single dose
or repeated dose 14 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
500 mg/kg bw
- No. of animals per sex per dose / concentration:
- 20
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- no indication of accumulation
- Type:
- excretion
- Results:
- 38-43% in urine, 54-62% in faeces with 168 h total excretion
- Type:
- metabolism
- Results:
- hydroxylation of side chain, ether cleavage, ring opening of methylendioxy-ring
Metabolite characterisation studies
- Metabolites identified:
- yes
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
PBO is well absorbed and distributed throughout the body. The molecule is extensively metabolised and fully excreted via urine, bile and faeces. - Executive summary:
A number of studies on toxicokinetiscs and metabolism have been performed in rats and mice.
Upon oral administration PBO is well absorbed and distributed throughout the body. The molecule is extensively metabolised and fully excreted via urine, bile and faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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