Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-076-7 | CAS number: 51-03-6
Bioaccumulation: terrestrial
Administrative data
Link to relevant study record(s)
Description of key information
There is no measured data on bioconcentration for PBO available. Based on the measured partition coefficient n-octanol/water (log Kow = 5) in the study of Comb A. L. (2008), PBO may have a potential for bioaccumulation. However, the BCF was estimated by QSAR (BCFBAF v3.00), and the resulting value was 39.06 L/kg wet weight. Furthermore according to mammalian toxicity data, Piperonyl butoxide is not classified as very toxic (T+), Toxic (T) or harmful (Xn) and does not carry the risk phrases R48, R60, R61, R62, R63 or R64. Additionally in an acute oral toxicity study with mammals a group of 6 female rats received a single dose of 2000 mg/kg bw neat Piperonyl butoxide by gavage. There were no mortalities and no clinical signs. Body weights were not affected and no pathological changes were observed. LD50 (rat, oral) exceeded 2000 mg/kg bw. Therefore, PBO is not regarded as bioaccumulative.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
