Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-487-4 | CAS number: 83-56-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Although rather limited documentation most important information is available
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological evaluation of Dihydroxynaphthalene , important components of oxidation hair dyes
- Author:
- Wallat S, Bartnik F, Kästner W, Maak N, Potokar M.
- Year:
- 1 985
- Bibliographic source:
- Aerztl.Kosmetol. 15, 356-364
Materials and methods
- Principles of method if other than guideline:
- The test substance was formulated into a so-called basic-cream with a ph about 9.5. the formulations were applied to the back skin of the test rat - shaved 24 hours before applicaion. To prevent oral uptake of the applied radioactivity the treated skin area was covered with a specially designed perforated glass capsule; treatment time: 48 hours
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Naphthalene-1,5-diol
- EC Number:
- 201-487-4
- EC Name:
- Naphthalene-1,5-diol
- Cas Number:
- 83-56-7
- Molecular formula:
- C10H8O2
- IUPAC Name:
- naphthalene-1,5-diol
- Test material form:
- other: cristalline powder
- Details on test material:
- HPLC: no impurities
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: a so-called basic cream with a pH of about 9.5
- Duration of exposure:
- 48 hours
- Doses:
- no data
- No. of animals per group:
- no data
- Control animals:
- no
- Details on study design:
- The test substance was formulated into a so-called basic-cream with a ph about 9.5. the formulations were applied to the back skin of the test rat - shaved 24 hours before applicaion. To prevent oral uptake of the applied radioactivity the treated skin area was covered with a specially designed perforated glass capsule; treatment time: 48 hours
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- no data
- Total recovery:
- no data
Percutaneous absorption
- Dose:
- no data
- Parameter:
- percentage
- Absorption:
- >= 7.7 - <= 9.5 %
- Remarks on result:
- other: 48 hours
Applicant's summary and conclusion
- Executive summary:
The test substance was formulated into a so-called basic-cream with a ph about 9.5. the formulations were applied to the back skin of the test rat - shaved 24 hours before application. To prevent oral uptake of the applied radioactivity the treated skin area was covered with a specially designed perforated glass capsule; treatment time: 48 hours. The absorption rate ranges between 7.7 and 9.5 %
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
