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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: although rather limited documentation most important information is available

Data source

Reference
Reference Type:
publication
Title:
Toxicological evaluation of Dihydroxynaphthalene , important components of oxidation hair dyes
Author:
Wallat S, Bartnik F, Kästner W, Maak N, Potokar M.
Year:
1985
Bibliographic source:
Aerztl.Kosmetol. 15, 356-364

Materials and methods

Objective of study:
other: absorption and excretion
Principles of method if other than guideline:
Oral administration of doses of 10 mg/kg bw to rats; the extent and rate of excretion was determined
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Naphthalene-1,5-diol
EC Number:
201-487-4
EC Name:
Naphthalene-1,5-diol
Cas Number:
83-56-7
Molecular formula:
C10H8O2
IUPAC Name:
naphthalene-1,5-diol
Test material form:
other: cristalline powder
Details on test material:
HPLC: no impurities
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on exposure:
the extent and rate of intestinal resorption and excretion was determined after oral administration of doses of 10 mg/kg bw
Duration and frequency of treatment / exposure:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
10 mg/kg bw
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified
Positive control reference chemical:
no data
Details on study design:
the extent and rate of intestinal resorption and excretion was determined after oral administration of doses of 10 mg/kg bw
Details on dosing and sampling:
the extent and rate of excretion was determined after oral administration of doses of 10 mg/kg bw
Statistics:
no data

Results and discussion

Main ADME resultsopen allclose all
Type:
excretion
Results:
within 24 hours: via urine 94.3 %;; via feces 6.2 %
Type:
other: intestinal resorption
Results:
the test substance was intestinally resorbed rapidly

Toxicokinetic / pharmacokinetic studies

Details on absorption:
after a single oral administration of 10 mg/kg bw of 1,5-di- hydroxynaphthalene (14C-labelled) to rats, the test substance was intestinally resorbed rapidly (details not given)
Details on distribution in tissues:
details not given
Details on excretion:
within 24 hours: 94.3 % via urine and 6.2 % via feces

Metabolite characterisation studies

Metabolites identified:
not specified
Details on metabolites:
no data

Applicant's summary and conclusion

Executive summary:

Single oral application of 10 mg/kg bw 1,5 -naphthalenediol to rats was intestinally resorbed rapidly and almost
completely excreted within 24 hours mainly via urine (94.3%) and small amounts (6.2 %) via feces