Registration Dossier
Registration Dossier
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EC number: 203-253-7 | CAS number: 104-93-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Remarks:
- ; GLP was not compulsory at the time the study was conducted.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-methylanisole
- EC Number:
- 203-253-7
- EC Name:
- 4-methylanisole
- Cas Number:
- 104-93-8
- Molecular formula:
- C8H10O
- IUPAC Name:
- 1-methoxy-4-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): p-Methylanisole
- Analytical purity: no data given
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: approx. 240 cm2
- Type of wrap if used: Cover was a sleeve and Webril padding
- Test site was clipped and left intact in half of the animals, while lightly abraded in the remaining animals
- Amount(s) applied: 5 ml/kg bw - Duration of exposure:
- 14 days
- Doses:
- 5 ml/kg bw => 4850 mg/kg bw (calculated using density : 970 g/l)
- No. of animals per sex per dose:
- 6 animals per dose (no further data)
- Control animals:
- not specified
- Details on study design:
- Toxic effects and mortality were recorded daily for 14 days
Pathology: gross necropsy
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 850 mg/kg bw
- Remarks on result:
- other: >5 ml/kg bw (calculation based on a density of 970 g/l)
- Mortality:
- No deaths occured, all animals survived.
- Clinical signs:
- Erythema score: 2-3 in 6/6 animals
Edema score: 1-3 in 5/6 animals
Scaling in 5/6 animals
Eschar in 3/6 animals
According to the authors, no other effects were seen. - Gross pathology:
- According to the authors, no effects were seen.
Applicant's summary and conclusion
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